Changes in hemostasis parameters after LPS administration
. | . | Time after LPS-containing pump implantation . | . | . | ||
|---|---|---|---|---|---|---|
| Parameter and genotype . | 0 h* . | 6 h . | 24 h . | 48 h . | ||
| PT, sec (no. mice) | ||||||
| WT | 11.2 ± 0.1 (13) | 12.5 ± 0.4 (12) | 13.2 ± 0.8 (12) | 16.5 ± 1.8 (11) | ||
| EPCRδ/δ | 11.2 ± 0.3 (8) | 12.0 ± 0.2 (13) | 16.0 ± 1.6 (12) | 27.8 ± 4.8 (10)† | ||
| aPTT, sec | ||||||
| WT | 33.4 ± 1.0 (13) | 43.0 ± 3.1 (12) | 58.5 ± 5.6 (12) | 124.6 ± 15.1 (11) | ||
| EPCRδ/δ | 34.4 ± 2.5 (8) | 33.9 ± 7.6 (13) | 88.0 ± 9.8 (12)† | 164.8 ± 8.8 (10)† | ||
| Platelets, × 109/L (no. mice) | ||||||
| WT | 404 ± 21 (13) | 225 ± 17 (12) | 207 ± 16 (12) | 195 ± 19 (11) | ||
| EPCRδ/δ | 387 ± 14 (8) | 174 ± 20 (13) | 153 ± 14 (12)† | 128 ± 14 (10)† | ||
| FVII, % (no. mice) | ||||||
| WT | 100 ± 1 (13) | 98 ± 5 (12) | 89 ± 4 (12) | 93 ± 11 (11) | ||
| EPCRδ/δ | 99 ± 2 (8) | 102 ± 3 (13) | 84 ± 5 (12) | 73 ± 7 (10) | ||
| FXII, % (no. mice) | ||||||
| WT | 100 ± 5 (13) | 105 ± 14 (12) | 56 ± 9 (12) | 32 ± 4 (11) | ||
| EPCRδ/δ | 113 ± 13 (8) | 95 ± 9 (13) | 47 ± 7 (12) | 17 ± 3 (10)† | ||
| Fibrinogen, μM/L (no. mice) | ||||||
| WT | 6.94 ± 0.47 (13) | 10.41 ± 0.59 (12) | 16.06 ± 2.12 (12) | 22.15 ± 1.56 (11) | ||
| EPCRδ/δ | 5.99 ± 0.44 (8) | 11.53 ± 1.88 (13) | 11.50 ± 1.06 (12) | 17.70 ± 1.00 (10)† | ||
. | . | Time after LPS-containing pump implantation . | . | . | ||
|---|---|---|---|---|---|---|
| Parameter and genotype . | 0 h* . | 6 h . | 24 h . | 48 h . | ||
| PT, sec (no. mice) | ||||||
| WT | 11.2 ± 0.1 (13) | 12.5 ± 0.4 (12) | 13.2 ± 0.8 (12) | 16.5 ± 1.8 (11) | ||
| EPCRδ/δ | 11.2 ± 0.3 (8) | 12.0 ± 0.2 (13) | 16.0 ± 1.6 (12) | 27.8 ± 4.8 (10)† | ||
| aPTT, sec | ||||||
| WT | 33.4 ± 1.0 (13) | 43.0 ± 3.1 (12) | 58.5 ± 5.6 (12) | 124.6 ± 15.1 (11) | ||
| EPCRδ/δ | 34.4 ± 2.5 (8) | 33.9 ± 7.6 (13) | 88.0 ± 9.8 (12)† | 164.8 ± 8.8 (10)† | ||
| Platelets, × 109/L (no. mice) | ||||||
| WT | 404 ± 21 (13) | 225 ± 17 (12) | 207 ± 16 (12) | 195 ± 19 (11) | ||
| EPCRδ/δ | 387 ± 14 (8) | 174 ± 20 (13) | 153 ± 14 (12)† | 128 ± 14 (10)† | ||
| FVII, % (no. mice) | ||||||
| WT | 100 ± 1 (13) | 98 ± 5 (12) | 89 ± 4 (12) | 93 ± 11 (11) | ||
| EPCRδ/δ | 99 ± 2 (8) | 102 ± 3 (13) | 84 ± 5 (12) | 73 ± 7 (10) | ||
| FXII, % (no. mice) | ||||||
| WT | 100 ± 5 (13) | 105 ± 14 (12) | 56 ± 9 (12) | 32 ± 4 (11) | ||
| EPCRδ/δ | 113 ± 13 (8) | 95 ± 9 (13) | 47 ± 7 (12) | 17 ± 3 (10)† | ||
| Fibrinogen, μM/L (no. mice) | ||||||
| WT | 6.94 ± 0.47 (13) | 10.41 ± 0.59 (12) | 16.06 ± 2.12 (12) | 22.15 ± 1.56 (11) | ||
| EPCRδ/δ | 5.99 ± 0.44 (8) | 11.53 ± 1.88 (13) | 11.50 ± 1.06 (12) | 17.70 ± 1.00 (10)† | ||