Table 3. Treatment options and response... | American Society of Hematology

Table 3.

Treatment options and response of IPSID

Stage of disease	Treatment	Overall response
1. Early bowel wall involvement; no visible tumor	1. Antibiotics: tetracycline, 1 g/d for 6 mo^16,17,19,22	30%-70% CR lasting months to several years
	2. Metronidazole plus ampicillin/tetracycline⁶²	43% 5-y DFS
	3. H pylori regimen for 7 d (1 patient)⁶³	5+ mo
	4. C jejuni treatment with H pylori regimen for 5 mo (1 patient)²⁶	12+ mo
2. Advanced disease with bowel wall tumor formation with or without mesenteric node involvement	Anthracycline-based combination chemotherapy ± tetracycline^30,64,65	50%-60% CR lasting months to years (60%-70% DFS at 3 y)
3. Advanced bulky tumor with mechanical complications	Corrective surgery, palliative radiation therapy, combination chemotherapy^16,19,22	Partial response, few months to less than 1 y

Stage of disease	Treatment	Overall response
1. Early bowel wall involvement; no visible tumor	1. Antibiotics: tetracycline, 1 g/d for 6 mo^16,17,19,22	30%-70% CR lasting months to several years
	2. Metronidazole plus ampicillin/tetracycline⁶²	43% 5-y DFS
	3. H pylori regimen for 7 d (1 patient)⁶³	5+ mo
	4. C jejuni treatment with H pylori regimen for 5 mo (1 patient)²⁶	12+ mo
2. Advanced disease with bowel wall tumor formation with or without mesenteric node involvement	Anthracycline-based combination chemotherapy ± tetracycline^30,64,65	50%-60% CR lasting months to years (60%-70% DFS at 3 y)
3. Advanced bulky tumor with mechanical complications	Corrective surgery, palliative radiation therapy, combination chemotherapy^16,19,22	Partial response, few months to less than 1 y