Mapping of integration sites
Int. ID . | Chromosomal band . | Chromosomal position, bp . | Trapped gene name/ref seq gene ID . | Trapped gene description . | Trap orientation relative to gene transcription . | Distance from TSS, kb . | Position within transcription unit . | Putative reporter transcript . |
|---|---|---|---|---|---|---|---|---|
| LT8 | 5q23.3 | 131666449 | PDLIM4 | LIM protein RIL (reversion-induced LIM protein) | Sense | 3 | Intron 1 | 5′ UTR fusion |
| NM_003687 | ||||||||
| LT1 | 15q22.2 | 57692244 | BNIP2 | BCL2/adenovirus E1B 19-kDa interacting protein 2 | Sense | 5 | Intron 1 | 5′ UTR fusion |
| NM_004330 | ||||||||
| LTA4 | 17p1 3.2 | 4470248 | UBE2G1 | Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, Caenorhabditis elegans) | Sense | 5 | Intron 1 | In-frame fusion with protein coding mRNA |
| NM_003342 | ||||||||
| NM_182682 | ||||||||
| LT2 | 3p21.1 | 49785970 | IHPK1 | Inositol hexaphosphate kinase 1 | Sense | 13 | Intron 1 | In-frame fusion with protein coding mRNA |
| NM_153273 | ||||||||
| LTA3 | 6p21.31 | 35685569 | FKBP5 | FK506 binding protein 5 | Sense | 16 | Intron 1 or intron 3, depending on alternative promoter | In-frame fusion with protein coding mRNA |
| NM_004117 | ||||||||
| LT3 | 2q31.1 | 172195652 | TLK1 | Tousled-like kinase 1 | Sense | 24 | Intron 1 | In-frame fusion with protein coding mRNA |
| NM_022644 | ||||||||
| LTA10 | 10q26.11 | 12014001 | C10orf46 | Chromosome 10 open reading frame 46 | Sense | 40 | Intron 3 | Fusion with an untranslated splicing isoform (C10orf46003) |
| NM_153810 | ||||||||
| LTA1 | 4q13.3 | 7230830 | MOBKL1A | MOB1, Mps One Binder kinase activator-like 1A (yeast) | Antisense* | 40* | Intron 4* | Fusion with natural antisentisense transcripts |
| NM_173468 | ||||||||
| LT10 | 17q23.3 | 62422791 | CSH2 | Chorionic somatomammotropin hormone 2 | Antisense* | 1.7* | Exon 4* | Fusion with natural antisentisense transcripts |
| NM_022646 | ||||||||
| NM_022645 | ||||||||
| NM_022644 | ||||||||
| NM_020991 | ||||||||
| LTA13 | 19q13.43 | 62696928 | FLJ23233 | Hypothetical protein FLJ23233 | Antisense* | 16* | Exon 5* | Fusion with natural antisentisense transcripts |
| NM_024691 | ||||||||
| RT15.8 | 6p21.31 | 35745703 | FKBP5 | FK506 binding protein 5 | Sense | -2 | Upstream TSS, downstream predicted promoter† | Reporter transcript without fusion to endogenous mRNA |
| NM_004117 | ||||||||
| RT15.10 | Xq21.1 | 75907912 | DKFZp564K142 | Implantation-associated protein | Sense | -1.1 | Upstream TSS, downstream predicted promoter† | Reporter transcript without fusion with endogenous mRNA |
| NM_032121 | ||||||||
| RT16.2 | 20q13.32 | 57911395 | STK16 | Serine/threonine kinase 16 | Sense | -0.4 | Upstream TSS, downstream predicted promoter† | Reporter transcript without fusion with endogenous mRNA |
| NM_003691 | ||||||||
| RT13 | 3q11.2 | 98965659 | EST: | NA | Sense | 0.1 | Unknown | EST fusion |
| BM676895.1 | ||||||||
| RT5.6 | 19p13.3 | 2895544 | ZNF77 | Zinc finger protein 77 (pT1) | Sense | 0.2 | Intron 1 | In-frame fusion protein |
| NM_021217 | ||||||||
| RT6.1 | 16p13.3 | 679892 | DKFZp434F054 | Hypothetical protein DKFZp434F054 | Sense | 0.5 | Exon 1 or intron 2 depending on alternative splicing | 5′ UTR fusion or inframe fusion protein depending on alternative splicing |
| NM_032259 | ||||||||
| RT25 | 20q13.33 | 62983740 | GMEB2 | Glucocorticoid modulatory element binding protein 2 | Sense | 1 | Intron 1 | 5′ UTR fusion |
| NM_012384 | ||||||||
| RT7.6 | 19p13.3 | 1215668 | UNIGENE ID: | NA | Sense | 1.5 | Putative Exon 4 | Fusion with untranslated ESTs |
| Hs79706 | ||||||||
| Hs322473 | ||||||||
| Hs383245 | ||||||||
| RT12 | 22q12.3 | 34330975 | MB | Myoglobin | Sense | 6 | Intron 2 | In-frame fusion protein |
| NM_203377 | ||||||||
| NM_005368 | ||||||||
| NM_203378 | ||||||||
| RT23 | 22q12.1 | 27383168 | cB42E1.c22.1 | NA | Antisense* | 17* | Intron 1 | Fusion with natural antisentisense transcripts? |
Int. ID . | Chromosomal band . | Chromosomal position, bp . | Trapped gene name/ref seq gene ID . | Trapped gene description . | Trap orientation relative to gene transcription . | Distance from TSS, kb . | Position within transcription unit . | Putative reporter transcript . |
|---|---|---|---|---|---|---|---|---|
| LT8 | 5q23.3 | 131666449 | PDLIM4 | LIM protein RIL (reversion-induced LIM protein) | Sense | 3 | Intron 1 | 5′ UTR fusion |
| NM_003687 | ||||||||
| LT1 | 15q22.2 | 57692244 | BNIP2 | BCL2/adenovirus E1B 19-kDa interacting protein 2 | Sense | 5 | Intron 1 | 5′ UTR fusion |
| NM_004330 | ||||||||
| LTA4 | 17p1 3.2 | 4470248 | UBE2G1 | Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, Caenorhabditis elegans) | Sense | 5 | Intron 1 | In-frame fusion with protein coding mRNA |
| NM_003342 | ||||||||
| NM_182682 | ||||||||
| LT2 | 3p21.1 | 49785970 | IHPK1 | Inositol hexaphosphate kinase 1 | Sense | 13 | Intron 1 | In-frame fusion with protein coding mRNA |
| NM_153273 | ||||||||
| LTA3 | 6p21.31 | 35685569 | FKBP5 | FK506 binding protein 5 | Sense | 16 | Intron 1 or intron 3, depending on alternative promoter | In-frame fusion with protein coding mRNA |
| NM_004117 | ||||||||
| LT3 | 2q31.1 | 172195652 | TLK1 | Tousled-like kinase 1 | Sense | 24 | Intron 1 | In-frame fusion with protein coding mRNA |
| NM_022644 | ||||||||
| LTA10 | 10q26.11 | 12014001 | C10orf46 | Chromosome 10 open reading frame 46 | Sense | 40 | Intron 3 | Fusion with an untranslated splicing isoform (C10orf46003) |
| NM_153810 | ||||||||
| LTA1 | 4q13.3 | 7230830 | MOBKL1A | MOB1, Mps One Binder kinase activator-like 1A (yeast) | Antisense* | 40* | Intron 4* | Fusion with natural antisentisense transcripts |
| NM_173468 | ||||||||
| LT10 | 17q23.3 | 62422791 | CSH2 | Chorionic somatomammotropin hormone 2 | Antisense* | 1.7* | Exon 4* | Fusion with natural antisentisense transcripts |
| NM_022646 | ||||||||
| NM_022645 | ||||||||
| NM_022644 | ||||||||
| NM_020991 | ||||||||
| LTA13 | 19q13.43 | 62696928 | FLJ23233 | Hypothetical protein FLJ23233 | Antisense* | 16* | Exon 5* | Fusion with natural antisentisense transcripts |
| NM_024691 | ||||||||
| RT15.8 | 6p21.31 | 35745703 | FKBP5 | FK506 binding protein 5 | Sense | -2 | Upstream TSS, downstream predicted promoter† | Reporter transcript without fusion to endogenous mRNA |
| NM_004117 | ||||||||
| RT15.10 | Xq21.1 | 75907912 | DKFZp564K142 | Implantation-associated protein | Sense | -1.1 | Upstream TSS, downstream predicted promoter† | Reporter transcript without fusion with endogenous mRNA |
| NM_032121 | ||||||||
| RT16.2 | 20q13.32 | 57911395 | STK16 | Serine/threonine kinase 16 | Sense | -0.4 | Upstream TSS, downstream predicted promoter† | Reporter transcript without fusion with endogenous mRNA |
| NM_003691 | ||||||||
| RT13 | 3q11.2 | 98965659 | EST: | NA | Sense | 0.1 | Unknown | EST fusion |
| BM676895.1 | ||||||||
| RT5.6 | 19p13.3 | 2895544 | ZNF77 | Zinc finger protein 77 (pT1) | Sense | 0.2 | Intron 1 | In-frame fusion protein |
| NM_021217 | ||||||||
| RT6.1 | 16p13.3 | 679892 | DKFZp434F054 | Hypothetical protein DKFZp434F054 | Sense | 0.5 | Exon 1 or intron 2 depending on alternative splicing | 5′ UTR fusion or inframe fusion protein depending on alternative splicing |
| NM_032259 | ||||||||
| RT25 | 20q13.33 | 62983740 | GMEB2 | Glucocorticoid modulatory element binding protein 2 | Sense | 1 | Intron 1 | 5′ UTR fusion |
| NM_012384 | ||||||||
| RT7.6 | 19p13.3 | 1215668 | UNIGENE ID: | NA | Sense | 1.5 | Putative Exon 4 | Fusion with untranslated ESTs |
| Hs79706 | ||||||||
| Hs322473 | ||||||||
| Hs383245 | ||||||||
| RT12 | 22q12.3 | 34330975 | MB | Myoglobin | Sense | 6 | Intron 2 | In-frame fusion protein |
| NM_203377 | ||||||||
| NM_005368 | ||||||||
| NM_203378 | ||||||||
| RT23 | 22q12.1 | 27383168 | cB42E1.c22.1 | NA | Antisense* | 17* | Intron 1 | Fusion with natural antisentisense transcripts? |
Int. ID indicates integration ID; NA, not available.
Relative to the known gene at the targeted locus. Because of the occurrence of natural antisense transcripts (NATs) for this gene, reporter expression may be driven by these transcripts for which no information is available on TSS and intron/exon organization
Integration occurred upstream of the putative TSS of the targeted gene. First EF and eponine algorithms identified putative promoters in the region, some of which may drive reporter expression