Acute hematologic and nonhematologic toxicity according to the WHO classification26 following ASCT and IFN, respectively
WHO toxicity . | IFN, % . | ASCT, % . |
|---|---|---|
| Acute hematologic toxicity | ||
| Anemia | ||
| Grades I/II | 21 | 45 |
| Grades III/IV | 0 | 45 |
| Leukocytopenia | ||
| Grades I/II | 43 | 2 |
| Grades III/IV | 42 | 95 |
| Granulocytopenia | ||
| Grades I/II | 30 | 2 |
| Grades III/IV | 36 | 84 |
| Thrombocytopenia | ||
| Grades I/II | 8 | 3 |
| Grades III/IV | 2 | 91 |
| Acute nonhematologic toxicity | ||
| Mucositis | ||
| Grades I/II | 9 | 41 |
| Grades III/IV | 0 | 33 |
| Infections | ||
| Grades I/II | 20 | 62 |
| Grades III/IV | 2 | 23 |
| Nausea | ||
| Grades I/II | 15 | 55 |
| Grades III/IV | 0 | 11 |
| Diarrhea | ||
| Grades I/II | 7 | 31 |
| Grades III/IV | 4 | 16 |
| Alopecia | ||
| Grades I/II | 22 | 2 |
| Grades III/IV | 54 | 81 |
| Liver | ||
| Grades I/II | 14 | 40 |
| Grades III/IV | 0 | 8 |
| Renal | ||
| Grades I/II | 0 | 15 |
| Grades III/IV | 0 | 2 |
| Pulmonary | ||
| Grades I/II | 0 | 11 |
| Grades III/IV | 0 | 6 |
| Muscle/bone pain | ||
| Grades I/II | 20 | 19 |
| Grades III/IV | 6 | 0 |
| Depression | ||
| Grades I/II | 9 | 7 |
| Grades III/IV | 6 | 2 |
WHO toxicity . | IFN, % . | ASCT, % . |
|---|---|---|
| Acute hematologic toxicity | ||
| Anemia | ||
| Grades I/II | 21 | 45 |
| Grades III/IV | 0 | 45 |
| Leukocytopenia | ||
| Grades I/II | 43 | 2 |
| Grades III/IV | 42 | 95 |
| Granulocytopenia | ||
| Grades I/II | 30 | 2 |
| Grades III/IV | 36 | 84 |
| Thrombocytopenia | ||
| Grades I/II | 8 | 3 |
| Grades III/IV | 2 | 91 |
| Acute nonhematologic toxicity | ||
| Mucositis | ||
| Grades I/II | 9 | 41 |
| Grades III/IV | 0 | 33 |
| Infections | ||
| Grades I/II | 20 | 62 |
| Grades III/IV | 2 | 23 |
| Nausea | ||
| Grades I/II | 15 | 55 |
| Grades III/IV | 0 | 11 |
| Diarrhea | ||
| Grades I/II | 7 | 31 |
| Grades III/IV | 4 | 16 |
| Alopecia | ||
| Grades I/II | 22 | 2 |
| Grades III/IV | 54 | 81 |
| Liver | ||
| Grades I/II | 14 | 40 |
| Grades III/IV | 0 | 8 |
| Renal | ||
| Grades I/II | 0 | 15 |
| Grades III/IV | 0 | 2 |
| Pulmonary | ||
| Grades I/II | 0 | 11 |
| Grades III/IV | 0 | 6 |
| Muscle/bone pain | ||
| Grades I/II | 20 | 19 |
| Grades III/IV | 6 | 0 |
| Depression | ||
| Grades I/II | 9 | 7 |
| Grades III/IV | 6 | 2 |
IFN indicates α-interferon maintenance; and ASCT, autologous stem cell transplantation.