Table 1. Characterization of splice... | American Society of Hematology

Table 1.

Characterization of splice variants and mutant forms of the FANCD2 protein compared with wild-type FANCD2

	Monoubiquitin on K561	Detected in chromatin	Forms nuclear foci	Corrects MMC sensitivity
FANCD2-43	+	ND	+	-
FANCD2-44	+*	+	+*	+*
Exon44-T	+	+	+	-
Mutant EDGE, D1428A	+	+	+	-
K561R	-*	-	-*	-*

	Monoubiquitin on K561	Detected in chromatin	Forms nuclear foci	Corrects MMC sensitivity
FANCD2-43	+	ND	+	-
FANCD2-44	+*	+	+*	+*
Exon44-T	+	+	+	-
Mutant EDGE, D1428A	+	+	+	-
K561R	-*	-	-*	-*

ND indicates not determined.

Data reported in Garcia-Higuera et al.¹⁰