Acceptance of donor platelets and induction of tolerance
. | . | Specific tolerance . | . | Nonspecific tolerance . | . | ||
|---|---|---|---|---|---|---|---|
| Initial donor platelet modification . | Acceptance of initial donor's treated platelets . | Initial donor, C-LR platelets . | Initial donor, STD platelets . | Third-party donors,*C-LR platelets . | Third-party donors,*STD platelets . | ||
| None, STD platelets, no. accepting/no. recipients (%) | 1/7 (14) | ND | ND | ND | 0/5 (0) | ||
| Range, % | 0-58 | NA | NA | NA | 0-45 | ||
| Single-treatment programs | |||||||
| C-LR, no. accepting/no. recipients (%) | 3/21 (14) | 1/3 (33) | ND | ND | ND | ||
| Range, % | 3-36 | 1-91 | NA | NA | NA | ||
| F-LR | |||||||
| Filtered × 1, no. accepting/no. recipients (%) | 3/8 (38) | 2/3 (67) | ND | 2/8 (25) | ND | ||
| Filtered × 2, no. accepting/no. recipients (%) | 1/5 (20) | 1/1 (100) | ND | 1/5 (20) | ND | ||
| Total, no. accepting/no. recipients (%) | 4/13 (31) | 3/4 (75) | ND | 3/13 (23) | ND | ||
| Range, % | 9-61 | 19-99 | NA | 5-54 | NA | ||
| Combined-treatment programs | |||||||
| F-LR/C-LR, no. accepting/no. recipients (%) | 13/15 (87) | 10/10 (100) | 7/9 (78) | 10/11 (91) | 3/8 (38) | ||
| Range, % | 60-98 | 74-100 | 40-97 | 59-100 | 8-75 | ||
| F-LR/C-LR + plasma, no. accepting/no. recipients (%) | 4/4 (100) | 4/4 (100) | 4/4 (100) | 4/4 (100) | 2/4 (50) | ||
| Range, % | 47-100 | 47-100 | 47-100 | 47-100 | 7-93 | ||
| F-LR/C-LR + RBC, no. accepting/no. recipients (%) | 4/4 (100) | 3/4 (75) | 3/4 (75) | 3/4 (75) | 2/2 (100) | ||
| Range, % | 47-100 | 19-99 | 19-99 | 19-99 | 72-100 | ||
| Total F-LR/C-LR, non-γ, no. accepting/no. recipients (%) | 21/23 (91) | 17/18 (94) | 14/17 (82) | 17/19 (89) | 7/14 (50) | ||
| Range, % | 72-99 | 73-99 | 57-96 | 67-99 | 23-77 | ||
| γ-F-LR/C-LR, no. accepting/no. recipients (%) | 6/6 (100) | ND | 0/6 (0) | ND | 1/6 (17) | ||
| Range, % | 61-100 | NA | 0-39 | NA | 4-64 | ||
. | . | Specific tolerance . | . | Nonspecific tolerance . | . | ||
|---|---|---|---|---|---|---|---|
| Initial donor platelet modification . | Acceptance of initial donor's treated platelets . | Initial donor, C-LR platelets . | Initial donor, STD platelets . | Third-party donors,*C-LR platelets . | Third-party donors,*STD platelets . | ||
| None, STD platelets, no. accepting/no. recipients (%) | 1/7 (14) | ND | ND | ND | 0/5 (0) | ||
| Range, % | 0-58 | NA | NA | NA | 0-45 | ||
| Single-treatment programs | |||||||
| C-LR, no. accepting/no. recipients (%) | 3/21 (14) | 1/3 (33) | ND | ND | ND | ||
| Range, % | 3-36 | 1-91 | NA | NA | NA | ||
| F-LR | |||||||
| Filtered × 1, no. accepting/no. recipients (%) | 3/8 (38) | 2/3 (67) | ND | 2/8 (25) | ND | ||
| Filtered × 2, no. accepting/no. recipients (%) | 1/5 (20) | 1/1 (100) | ND | 1/5 (20) | ND | ||
| Total, no. accepting/no. recipients (%) | 4/13 (31) | 3/4 (75) | ND | 3/13 (23) | ND | ||
| Range, % | 9-61 | 19-99 | NA | 5-54 | NA | ||
| Combined-treatment programs | |||||||
| F-LR/C-LR, no. accepting/no. recipients (%) | 13/15 (87) | 10/10 (100) | 7/9 (78) | 10/11 (91) | 3/8 (38) | ||
| Range, % | 60-98 | 74-100 | 40-97 | 59-100 | 8-75 | ||
| F-LR/C-LR + plasma, no. accepting/no. recipients (%) | 4/4 (100) | 4/4 (100) | 4/4 (100) | 4/4 (100) | 2/4 (50) | ||
| Range, % | 47-100 | 47-100 | 47-100 | 47-100 | 7-93 | ||
| F-LR/C-LR + RBC, no. accepting/no. recipients (%) | 4/4 (100) | 3/4 (75) | 3/4 (75) | 3/4 (75) | 2/2 (100) | ||
| Range, % | 47-100 | 19-99 | 19-99 | 19-99 | 72-100 | ||
| Total F-LR/C-LR, non-γ, no. accepting/no. recipients (%) | 21/23 (91) | 17/18 (94) | 14/17 (82) | 17/19 (89) | 7/14 (50) | ||
| Range, % | 72-99 | 73-99 | 57-96 | 67-99 | 23-77 | ||
| γ-F-LR/C-LR, no. accepting/no. recipients (%) | 6/6 (100) | ND | 0/6 (0) | ND | 1/6 (17) | ||
| Range, % | 61-100 | NA | 0-39 | NA | 4-64 | ||
Data are presented as the acceptance rate: (no. accepting/no. recipients) × 100 and the 95% confidence intervals for the acceptance ratios are shown in parentheses. If the confidence intervals do not overlap for the comparison of interest, it can be assumed that the percentages differ by at least P ≤ .05.
ND indicates not determined; NA, not applicable.
Results in columns labeled “Third-party donors” give the acceptance rates based on the number of recipients who accepted platelets from at least one of their third-party donors