Patient characteristics
. | All patients . | First cohort . | Second cohort . | Third cohort . |
|---|---|---|---|---|
| No. patients | 76 | 27 | 18 | 31 |
| Sex, no. males/no. females | 44/32 | 17/10 | 12/6 | 15/16 |
| Age, mean (range), y | 47 (18-68) | 47 (19-64) | 47 (18-67) | 47 (28-68) |
| Time from diagnosis to enrollment, mean (range), d | 50 (9-90) | 51 (10-90) | 43 (9-90) | 50 (14-90) |
| Prior treatment with hydroxyurea, no. patients (%) | 59 (78) | 20 (74) | 14 (78) | 25 (81) |
| No prior treatment, no. patients (%) | 17 (22) | 7 (26) | 4 (22) | 6 (19) |
| Relative risk (according to Sokal) | ||||
| Low, no. patients (%) | 34 (45) | 14 (52) | 9 (50) | 11 (35) |
| Intermediate, no. patients (%) | 24 (31) | 9 (33) | 4 (22) | 11 (35) |
| High, no. patients (%) | 18 (24) | 4 (15) | 5 (28) | 9 (29) |
| Relative risk (according to Hasford) | ||||
| Low, no. patients (%) | 39 (51) | 14 (52) | 9 (50) | 16 (52) |
| Intermediate, no. patients (%) | 28 (37) | 11 (41) | 8 (44) | 9 (29) |
| High, no. patients (%) | 9 (12) | 2 (7) | 1 (6) | 6 (19) |
. | All patients . | First cohort . | Second cohort . | Third cohort . |
|---|---|---|---|---|
| No. patients | 76 | 27 | 18 | 31 |
| Sex, no. males/no. females | 44/32 | 17/10 | 12/6 | 15/16 |
| Age, mean (range), y | 47 (18-68) | 47 (19-64) | 47 (18-67) | 47 (28-68) |
| Time from diagnosis to enrollment, mean (range), d | 50 (9-90) | 51 (10-90) | 43 (9-90) | 50 (14-90) |
| Prior treatment with hydroxyurea, no. patients (%) | 59 (78) | 20 (74) | 14 (78) | 25 (81) |
| No prior treatment, no. patients (%) | 17 (22) | 7 (26) | 4 (22) | 6 (19) |
| Relative risk (according to Sokal) | ||||
| Low, no. patients (%) | 34 (45) | 14 (52) | 9 (50) | 11 (35) |
| Intermediate, no. patients (%) | 24 (31) | 9 (33) | 4 (22) | 11 (35) |
| High, no. patients (%) | 18 (24) | 4 (15) | 5 (28) | 9 (29) |
| Relative risk (according to Hasford) | ||||
| Low, no. patients (%) | 39 (51) | 14 (52) | 9 (50) | 16 (52) |
| Intermediate, no. patients (%) | 28 (37) | 11 (41) | 8 (44) | 9 (29) |
| High, no. patients (%) | 9 (12) | 2 (7) | 1 (6) | 6 (19) |