Table 1.

FTY720-induced lymphocyte redistribution in various lymphoid tissues during an immune response

Tissue and treatment
CD4+
CD8+
B220+
PMBC*    
Water   37.8 × 104 ± 3.2   34.8 × 104 ± 7.5   ND  
FTY   1.3 × 104 ± 0.1   2.0 × 104 ± 0.1   ND  
Spleen†    
Water   5.7 × 106 ± 0.2   3.9 × 106 ± 0.1   17.3 × 106 ± 0.2  
FTY   4.0 × 106 ± 0.2   2.5 × 106 ± 0.1   17.0 × 106 ± 0.6  
mLN‡    
Water   2.3 × 106 ± 0.5   1.7 × 106 ± 0.8   2.5 × 106 ± 0.5  
FTY   1.8 × 106 ± 0.3   2.0 × 106 ± 0.6   1.8 × 106 ± 0.5  
PP§    
Water   8.5 × 105 ± 2.2   2.1 × 105 ± 0.2   38.8 × 105 ± 5.3  
FTY
 		 10.0 × 105 ± 1.4
 		 2.4 × 105 ± 0.3
 		 37.8 × 105 ± 4.6
 
Tissue and treatment
CD4+
CD8+
B220+
PMBC*    
Water   37.8 × 104 ± 3.2   34.8 × 104 ± 7.5   ND  
FTY   1.3 × 104 ± 0.1   2.0 × 104 ± 0.1   ND  
Spleen†    
Water   5.7 × 106 ± 0.2   3.9 × 106 ± 0.1   17.3 × 106 ± 0.2  
FTY   4.0 × 106 ± 0.2   2.5 × 106 ± 0.1   17.0 × 106 ± 0.6  
mLN‡    
Water   2.3 × 106 ± 0.5   1.7 × 106 ± 0.8   2.5 × 106 ± 0.5  
FTY   1.8 × 106 ± 0.3   2.0 × 106 ± 0.6   1.8 × 106 ± 0.5  
PP§    
Water   8.5 × 105 ± 2.2   2.1 × 105 ± 0.2   38.8 × 105 ± 5.3  
FTY
 		 10.0 × 105 ± 1.4
 		 2.4 × 105 ± 0.3
 		 37.8 × 105 ± 4.6
 

Mice were treated with FTY720 once every 2 days and analyzed at day 14. ND indicated not done.

*

Number of cells in 1 mL blood.

†

Number of cells in 1 spleen.

‡

Number of cells from all mLNs.

§

Number of cell from all PP.

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