Clinical features of xmd dogs before and after HCT
Donor no./recipient no. . | Parents . | Age at HCT, d . | TBI, cGy . | % donor peripheral blood after HCT,*lymphocytes/monocytes . | Status after HCT . |
|---|---|---|---|---|---|
| G017 carrier/G019 | GR/Beagle | 135 | 920 | 100/100 | Dead d 406 (heart failure) |
| G119/G121 | GR/Beagle/Mini-Mongrel | 139 | 920 | 100/100 | Euthanized d 27 (intussusception) |
| G120 carrier/G122 | GR/Beagle/Mini-Mongrel | 153 | 200 | 90/70 | Euthanized d 31 (hypercalcemia) |
| G124/G123 | GR/Beagle/Mini-Mongrel | 166 | 920 | 100/100 | Euthanized d 306 (respiratory failure) |
| G124/G125 | GR/Beagle/Mini-Mongrel | 132 | 920 | 100/100 | Euthanized d 46 (intussusception) |
| G139 carrier/G141 | GR/GR | 145 | 920 | 100/90 | Alive d 745 (clinical disease progression) |
| G143/G142 | GR/GR | 137 | 920 | 100/100 | Alive d 750 (clinical disease progression) |
Donor no./recipient no. . | Parents . | Age at HCT, d . | TBI, cGy . | % donor peripheral blood after HCT,*lymphocytes/monocytes . | Status after HCT . |
|---|---|---|---|---|---|
| G017 carrier/G019 | GR/Beagle | 135 | 920 | 100/100 | Dead d 406 (heart failure) |
| G119/G121 | GR/Beagle/Mini-Mongrel | 139 | 920 | 100/100 | Euthanized d 27 (intussusception) |
| G120 carrier/G122 | GR/Beagle/Mini-Mongrel | 153 | 200 | 90/70 | Euthanized d 31 (hypercalcemia) |
| G124/G123 | GR/Beagle/Mini-Mongrel | 166 | 920 | 100/100 | Euthanized d 306 (respiratory failure) |
| G124/G125 | GR/Beagle/Mini-Mongrel | 132 | 920 | 100/100 | Euthanized d 46 (intussusception) |
| G139 carrier/G141 | GR/GR | 145 | 920 | 100/90 | Alive d 745 (clinical disease progression) |
| G143/G142 | GR/GR | 137 | 920 | 100/100 | Alive d 750 (clinical disease progression) |
No dog had graft-versus-host disease (GVHD).
HCT indicates hematopoietic cell transplantation; TBI, total body irradiation; GR, golden retriever; and d, day.
Percent donor chimerism was measured on a weekly basis after HCT. For the majority of dogs, values shown are those measured at autopsy. For G141 and G142, the chimerism was last evaluated on days 745 and 750 after HCT, respectively. C-xmd dogs were given DLA-identical HC transplants from their matched wild-type or carrier littermate. The graft consisted of donor marrow and G-CSF–mobilized peripheral blood