Analysis of wild-type, SHIP-1−/−, Mev/Mev, and Lyn−/− mouse HCT, spleen weight, and BM and spleen cellularity
Genotype (no. mice) . | HCT, % . | Spleen weight, g . | Spleen cellularity, × 106 . | BM cellularity/femur, × 106 . |
|---|---|---|---|---|
| Wild-type (8) | 52.4 ± 1.6 | 0.085 ± 0.012 | 135 ± 53 | 17.0 ± 2.1 |
| SHIP-1−/− (7) | 50.8 ± 4.6 | 0.213 ± 0.064 | 300 ± 93 | 13.4 ± 3.0 |
| Mev/Mev (4-6) | 43.7 ± 3.7 | 0.236 ± 0.091 | 298 ± 124 | 4.3 ± 0.9 |
| Lyn−/− (5) | 50.1 ± 2.4 | 0.087 ± 0.019 | 117 ± 9 | 18.2 ± 1.9 |
Genotype (no. mice) . | HCT, % . | Spleen weight, g . | Spleen cellularity, × 106 . | BM cellularity/femur, × 106 . |
|---|---|---|---|---|
| Wild-type (8) | 52.4 ± 1.6 | 0.085 ± 0.012 | 135 ± 53 | 17.0 ± 2.1 |
| SHIP-1−/− (7) | 50.8 ± 4.6 | 0.213 ± 0.064 | 300 ± 93 | 13.4 ± 3.0 |
| Mev/Mev (4-6) | 43.7 ± 3.7 | 0.236 ± 0.091 | 298 ± 124 | 4.3 ± 0.9 |
| Lyn−/− (5) | 50.1 ± 2.4 | 0.087 ± 0.019 | 117 ± 9 | 18.2 ± 1.9 |
All characterization was performed on mice of 6 to 8 weeks of age. Hematocrit (HCT) was determined by analysis of blood obtained from the retro-orbital venous plexus on an ADVIA 120 hematology system. Values represent the mean ± SD for the number of mice indicated.