Table 5. Apparent permeability of... | American Society of Hematology

Table 5.

Apparent permeability of imatinib across MDCK cell monolayers

	MDCK II cm/s × 10⁸	MDCK-MDR1 cm/s × 10⁸
Apical-basal	1.0 (0.22)	0.64 (0.03)
Basal-apical	2.1 (0.10)	4.6 (0.37)^*
Basal-apical + transport inhibitor	N/A	1.08 (0.04)†
Efflux ratio	2.1	7.2

	MDCK II cm/s × 10⁸	MDCK-MDR1 cm/s × 10⁸
Apical-basal	1.0 (0.22)	0.64 (0.03)
Basal-apical	2.1 (0.10)	4.6 (0.37)^*
Basal-apical + transport inhibitor	N/A	1.08 (0.04)†
Efflux ratio	2.1	7.2

Data are presented as mean (SEM).

Significantly different from apical-basal transport (P < .001)

Significantly different from basal-apical transport (P < .001)