Karyotypes of GCV-sensitive clone no. 1 and GCV-resistant subclone no. 1-3
Karyotype of clone no. 1 . | Karyotype of GCV-resistant subclone no. 1-3 . |
|---|---|
| 74-77, X, | 73-77, X, |
| Dup(XF4-5D), | Dup(XF4-5D), |
| Del(1F)×2, | Del(1F)×2, |
| T(2E;13A)×2, | T(2E;13A)×2, |
| Der(2)T(1F;2H)×2, | Der(2)T(1F;2H)×2, |
| Del(3F)×2, | Del(3F)×2, |
| Del(4D), | Del(4D), |
| T(5D;12C)×2, | T(5D;12C)×2, |
| -6, | -6, |
| Der(6)T(6D;11B2)T(11D;7F)×2, | Der(6)T(6D;11B2)T(11D;7F)×2, |
| Del(7E), | Del(7E), |
| Der(7)T(7F;11D)×2, | Der(7)T(7F;11D)×2, |
| Der(9)T(1F;9E)×2, | Der(9)T(1F;9E)×2, |
| +10, | +10, |
| ?T(10D;10B), | ?T(10D;10B), |
| Der(10)T(10D;1D)T(1F;9D)T(9F;7F)×2, | Der(10)T(10D;1D)T(1F;9D)T(9F;7F)×2, |
| Der(11)T(6D;11B2)×2, | Der(11)T(6D;11B2)×2, |
| Del(13A2A5)×2, | Del(13A2A5)×2, |
| -14, | -14, |
| Del(14B)×2, | Del(14B)×2, |
| Der(14)T(8E;14E), | Der(14)T(8E;14E), |
| +Del(15B)×2, | +Del(15B)×2, |
| Der(15)T(14B;15E)×2, | Der(15)T(14B;15E)×2, |
| RT(16;17)T(16C1;7F?2)T(7F?4;9F), | RT(16;17)T(16C1;7F?2)T(7F?4;9F), |
| Dic(7;16)(7B;16cen)T(16C1;7F?2)T(7F?4;9F), | Dic(7;16)(7B;16cen)T(16C1;7F?2)T(7F?4;9F), |
| Dic(7B;18cen)×2, | Dic(7B;18cen)×2 |
| Der(19)T(6B;19D) | Not detected |
Karyotype of clone no. 1 . | Karyotype of GCV-resistant subclone no. 1-3 . |
|---|---|
| 74-77, X, | 73-77, X, |
| Dup(XF4-5D), | Dup(XF4-5D), |
| Del(1F)×2, | Del(1F)×2, |
| T(2E;13A)×2, | T(2E;13A)×2, |
| Der(2)T(1F;2H)×2, | Der(2)T(1F;2H)×2, |
| Del(3F)×2, | Del(3F)×2, |
| Del(4D), | Del(4D), |
| T(5D;12C)×2, | T(5D;12C)×2, |
| -6, | -6, |
| Der(6)T(6D;11B2)T(11D;7F)×2, | Der(6)T(6D;11B2)T(11D;7F)×2, |
| Del(7E), | Del(7E), |
| Der(7)T(7F;11D)×2, | Der(7)T(7F;11D)×2, |
| Der(9)T(1F;9E)×2, | Der(9)T(1F;9E)×2, |
| +10, | +10, |
| ?T(10D;10B), | ?T(10D;10B), |
| Der(10)T(10D;1D)T(1F;9D)T(9F;7F)×2, | Der(10)T(10D;1D)T(1F;9D)T(9F;7F)×2, |
| Der(11)T(6D;11B2)×2, | Der(11)T(6D;11B2)×2, |
| Del(13A2A5)×2, | Del(13A2A5)×2, |
| -14, | -14, |
| Del(14B)×2, | Del(14B)×2, |
| Der(14)T(8E;14E), | Der(14)T(8E;14E), |
| +Del(15B)×2, | +Del(15B)×2, |
| Der(15)T(14B;15E)×2, | Der(15)T(14B;15E)×2, |
| RT(16;17)T(16C1;7F?2)T(7F?4;9F), | RT(16;17)T(16C1;7F?2)T(7F?4;9F), |
| Dic(7;16)(7B;16cen)T(16C1;7F?2)T(7F?4;9F), | Dic(7;16)(7B;16cen)T(16C1;7F?2)T(7F?4;9F), |
| Dic(7B;18cen)×2, | Dic(7B;18cen)×2 |
| Der(19)T(6B;19D) | Not detected |
The deletion of one of the chromosomes 4 described in the karyotype for clone no. 1 is unfortunately not as clearly recognizable in the resistant clone as in the sensitive clone shown in Figure 4, although it was detected in both clones. The additional chromosome 10 of clone no. 1 described is only absent in the metaphase shown in Figure 4. We analyzed 10 metaphases of each clone.