Kinetics of the number of the BCR-ABL transcripts copies for each patient
Patient . | At diagnosis . | On d 28 . | On d 63 . | After C1-1 . | After C2-1 . | After C1-3 . | After C2-3 . | At 1 y . |
|---|---|---|---|---|---|---|---|---|
| UPN 1 | 84 000 | N | N | < 50 | SIB-HSCT | — | — | — |
| UPN 2 | 2 800 000 | 540 | 260 | N | N | N | N | — |
| UPN 3 | 110 000 | — | < 50 | N | 240 000 | Relapse | — | — |
| UPN 4 | 440 000 | < 50 | N | N | N | N | — | N |
| UPN 5 | 93 000 | N | N | N | N | N | N | N |
| UPN 6 | 140 000 | 99 | N | N | 52 000 | Relapse | — | — |
| UPN 7 | 320 000 | < 50 | SIB-HSCT | — | — | — | — | — |
| UPN 8 | 56 000 | 1 000 | 62 | N | < 50 | < 50 | 1300 | UD-HSCT |
| UPN 9 | 110 000 | ED | — | — | — | — | — | — |
| UPN 10 | 3 500 000 | 73 | < 50 | 110 | 230 | UD-HSCT | — | — |
| UPN 11 | 150 000 | — | — | < 50 | < 50 | N | SIB-HSCT | — |
| UPN 12 | 510 000 | 440 | 8600 | 75 | CB-HSCT | — | — | — |
| UPN 13 | 1 200 000 | 270 | 190 | N | N | N | N | UD-HSCT |
| UPN 14 | 340 000 | 110 | N | — | N | — | 3400 | Relapse |
| UPN 15 | 7 200 000 | — | < 50 | < 50 | < 50 | N | UD-HSCT | — |
| UPN 16 | 290 000 | N | N | N | — | N | 290 | CB-HSCT |
| UPN 17 | 1 500 000 | 260 | < 50 | < 50 | 1 100 | Relapse | — | — |
| UPN 18 | 1 100 000 | — | N | < 50 | N | N | — | N |
| UPN 19 | 420 000 | 38 000 | < 50 | N | SIB-HSCT | — | — | — |
| UPN 20 | 4 600 000 | < 50 | < 50 | N | N | UD-HSCT | — | — |
| UPN 21 | 45 000 | < 50 | N | N | — | SIB-HSCT | — | — |
| UPN 22 | 1 800 000 | N | N | N | SIB-HSCT | — | — | — |
| UPN 23 | —* | — | — | — | — | UD-HSCT | — | — |
| UPN 24 | 2 400 000 | N | N | N | N | N | UD-HSCT | — |
Patient . | At diagnosis . | On d 28 . | On d 63 . | After C1-1 . | After C2-1 . | After C1-3 . | After C2-3 . | At 1 y . |
|---|---|---|---|---|---|---|---|---|
| UPN 1 | 84 000 | N | N | < 50 | SIB-HSCT | — | — | — |
| UPN 2 | 2 800 000 | 540 | 260 | N | N | N | N | — |
| UPN 3 | 110 000 | — | < 50 | N | 240 000 | Relapse | — | — |
| UPN 4 | 440 000 | < 50 | N | N | N | N | — | N |
| UPN 5 | 93 000 | N | N | N | N | N | N | N |
| UPN 6 | 140 000 | 99 | N | N | 52 000 | Relapse | — | — |
| UPN 7 | 320 000 | < 50 | SIB-HSCT | — | — | — | — | — |
| UPN 8 | 56 000 | 1 000 | 62 | N | < 50 | < 50 | 1300 | UD-HSCT |
| UPN 9 | 110 000 | ED | — | — | — | — | — | — |
| UPN 10 | 3 500 000 | 73 | < 50 | 110 | 230 | UD-HSCT | — | — |
| UPN 11 | 150 000 | — | — | < 50 | < 50 | N | SIB-HSCT | — |
| UPN 12 | 510 000 | 440 | 8600 | 75 | CB-HSCT | — | — | — |
| UPN 13 | 1 200 000 | 270 | 190 | N | N | N | N | UD-HSCT |
| UPN 14 | 340 000 | 110 | N | — | N | — | 3400 | Relapse |
| UPN 15 | 7 200 000 | — | < 50 | < 50 | < 50 | N | UD-HSCT | — |
| UPN 16 | 290 000 | N | N | N | — | N | 290 | CB-HSCT |
| UPN 17 | 1 500 000 | 260 | < 50 | < 50 | 1 100 | Relapse | — | — |
| UPN 18 | 1 100 000 | — | N | < 50 | N | N | — | N |
| UPN 19 | 420 000 | 38 000 | < 50 | N | SIB-HSCT | — | — | — |
| UPN 20 | 4 600 000 | < 50 | < 50 | N | N | UD-HSCT | — | — |
| UPN 21 | 45 000 | < 50 | N | N | — | SIB-HSCT | — | — |
| UPN 22 | 1 800 000 | N | N | N | SIB-HSCT | — | — | — |
| UPN 23 | —* | — | — | — | — | UD-HSCT | — | — |
| UPN 24 | 2 400 000 | N | N | N | N | N | UD-HSCT | — |
The detection threshold was 50 copies/μg RNA, and the levels under the threshold were distinguished between “not detected (N)” and “slightly detected (< 50).
N indicates negative for BCR-ABL transcript; SIB, sibling donor; HSCT, hematopoietic stem cell transplantation; —, RQ-PCR test not performed; UD, unrelated donor; ED, early death; and CB, cord blood.
The PCR test could not be performed and the diagnosis of BCR-ABL positivity was based on FISH analysis.