Table 5.

Multivariate Cox model for disease-free survival


Feature

Univariate analysis P

Multivariate analysis P
Global series   
    Methylation profile   <.0001   <.0001  
    WBC count higher than 50 × 109/L   .0002   .002  
    BCR-ABL positivity   .004   .01  
    T phenotype   .03   —  
    Age older than 15 years   .007   —  
    PETHEMA poor risk   .04   —  
Childhood ALL   
    Methylation profile   .0001   .0001  
    PETHEMA poor risk   .05   .05  
    WBC count higher than 50 × 109/L   .05   —  
    NCl poor risk   .05   —  
Adult ALL   
    BCR-ABL positivity   <.0001   .001  
    Methylation profile   .003   .006  
    WBC higher than 50 × 109/L
 
.0002
 
.02
 

Feature

Univariate analysis P

Multivariate analysis P
Global series   
    Methylation profile   <.0001   <.0001  
    WBC count higher than 50 × 109/L   .0002   .002  
    BCR-ABL positivity   .004   .01  
    T phenotype   .03   —  
    Age older than 15 years   .007   —  
    PETHEMA poor risk   .04   —  
Childhood ALL   
    Methylation profile   .0001   .0001  
    PETHEMA poor risk   .05   .05  
    WBC count higher than 50 × 109/L   .05   —  
    NCl poor risk   .05   —  
Adult ALL   
    BCR-ABL positivity   <.0001   .001  
    Methylation profile   .003   .006  
    WBC higher than 50 × 109/L
 
.0002
 
.02
 

— indicates not significant.

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