Table 3. Methylation profile in ALL... | American Society of Hematology

Table 3.

Methylation profile in ALL

Feature	Overall, %	Childhood ALL, %	Adult ALL, %
Methylated genes
NES-1	57	55	58
LATS-1*	40	30	47
CDH1*	37	32	42
CDH13	35	32	37
p16	35	32	36
APAF-1	34	35	34
DKK-3	33	32	33
p15*	29	20	38
PARKIN	27	30	24
PTEN	20	20	19
p57†	18	2	34
p73	18	18	18
DAPK	13	10	17
TMS-1	9	10	7
p14*	8.5	5	13
Methylation group
Nonmethylated‡	22.7	28.2	17.3
Methylated	77.3	71.8	82.7
Group A	41.4	38.7	44.1
Group B	35.9	33.1	38.6
No. methylated genes
0*	22.7	28.2	18.1
1	9.3	8.1	9.4
2	19.9	21	18.9
3	12.7	9.7	15.7
4	10	6.5	13.4
5	10	9.7	10.2
6	5.6	6.5	4.7
7	4.8	6.5	3.1
8	2	1.6	2.4
9	1.6	1.6	1.6
10	1.6	0.8	2.4

Feature	Overall, %	Childhood ALL, %	Adult ALL, %
Methylated genes
NES-1	57	55	58
LATS-1*	40	30	47
CDH1*	37	32	42
CDH13	35	32	37
p16	35	32	36
APAF-1	34	35	34
DKK-3	33	32	33
p15*	29	20	38
PARKIN	27	30	24
PTEN	20	20	19
p57†	18	2	34
p73	18	18	18
DAPK	13	10	17
TMS-1	9	10	7
p14*	8.5	5	13
Methylation group
Nonmethylated‡	22.7	28.2	17.3
Methylated	77.3	71.8	82.7
Group A	41.4	38.7	44.1
Group B	35.9	33.1	38.6
No. methylated genes
0*	22.7	28.2	18.1
1	9.3	8.1	9.4
2	19.9	21	18.9
3	12.7	9.7	15.7
4	10	6.5	13.4
5	10	9.7	10.2
6	5.6	6.5	4.7
7	4.8	6.5	3.1
8	2	1.6	2.4
9	1.6	1.6	1.6
10	1.6	0.8	2.4

P = .05.

P = .001.

P = .03.