Genes studied for methylation in ALL
Gene . | Location . | Function . | Reference for MSP primers . |
|---|---|---|---|
| NES-1 | 19q13 | Growth and differentiation control; putative TSG | Roman-Gomez et al21 |
| LATS-1 | 6q23-25 | TSG; G2-M cell cycle control; apoptosis regulation | Hisaoka et al29 |
| CDH1 | 16q22 | TSG; calcium-dependent cell-cell adhesion | Melki et al10 |
| CDH13 | 16q24 | Calcium-dependent cell-cell adhesion | Roman-Gomez et al23 |
| p16 | 9p21 | TSG; G1-S cell cycle control | Wong et al11 |
| APAF-1 | 12q23 | Apoptosis regulation | Fu et al26 |
| DKK-3 | 11p15 | Wnt/catenin signaling pathway antagonist; mortalization-related gene; putative TSG | Roman-Gomez et al22 |
| p15 | 9p21 | G1-S cell cycle control; putative TSG | Wong et al11 |
| PARKIN | 6q25-27 | E3 ubiquitin ligase; putative TSG | Cesari et al28 |
| PTEN | 10q23 | TSG; cell adhesion/motility; apoptosis; angiogenesis; G1 cell cycle regulation; signal transduction | Zysman et al30 |
| p57 | 11p15 | G1-S cell cycle control; putative TSG | Shen et al15 |
| p73 | 1p36 | G1-S cell cycle control; putative TSG | Kawano et al9 |
| DAPK | 9q34 | Apoptosis regulation | Katzenellenbogen et al27 |
| TMS-1 | 16p11-12 | Apoptosis regulation | Conway et al25 |
| p14 | 9p21 | Cell cycle control; apoptosis regulation | Esteller et al24 |
Gene . | Location . | Function . | Reference for MSP primers . |
|---|---|---|---|
| NES-1 | 19q13 | Growth and differentiation control; putative TSG | Roman-Gomez et al21 |
| LATS-1 | 6q23-25 | TSG; G2-M cell cycle control; apoptosis regulation | Hisaoka et al29 |
| CDH1 | 16q22 | TSG; calcium-dependent cell-cell adhesion | Melki et al10 |
| CDH13 | 16q24 | Calcium-dependent cell-cell adhesion | Roman-Gomez et al23 |
| p16 | 9p21 | TSG; G1-S cell cycle control | Wong et al11 |
| APAF-1 | 12q23 | Apoptosis regulation | Fu et al26 |
| DKK-3 | 11p15 | Wnt/catenin signaling pathway antagonist; mortalization-related gene; putative TSG | Roman-Gomez et al22 |
| p15 | 9p21 | G1-S cell cycle control; putative TSG | Wong et al11 |
| PARKIN | 6q25-27 | E3 ubiquitin ligase; putative TSG | Cesari et al28 |
| PTEN | 10q23 | TSG; cell adhesion/motility; apoptosis; angiogenesis; G1 cell cycle regulation; signal transduction | Zysman et al30 |
| p57 | 11p15 | G1-S cell cycle control; putative TSG | Shen et al15 |
| p73 | 1p36 | G1-S cell cycle control; putative TSG | Kawano et al9 |
| DAPK | 9q34 | Apoptosis regulation | Katzenellenbogen et al27 |
| TMS-1 | 16p11-12 | Apoptosis regulation | Conway et al25 |
| p14 | 9p21 | Cell cycle control; apoptosis regulation | Esteller et al24 |
MSP indicates methylation-specific polymerase chain reaction; TSG, tumor suppressor gene; E3, early region 3.