Table 3.

Hematologic and clinical features of patients with hypodiploidy with 30 to 39 chromosomes and near-triploidy




Hypodiploidy 30-39 chromosomes

Near-triploidy
No. patients   11   13  
Median age, y (range)   46 (15-73)   52 (21-73)  
Sex, no. male/no. female   5/6   8/5  
Median hemoglobin level, g/L   97   99  
Median WBC count, × 109/L (range)   4.5 (1.6-7.4)   4.2 (0.9-32.3)  
Median platelet count, × 109/L   55   45  
Immunophenotype*  B lineage   B lineage  
CD19+CD10-CD20-, % (no. patients)   27 (3)   16.6 (2)  
CD19+CD10+CD20+, % (no. patients)   73 (8)   83.3 (10)  
CR rates, %  70   46  
OS, mos.   11.1   8.1  
Median DFS, mos.
 
5
 
18.2
 



Hypodiploidy 30-39 chromosomes

Near-triploidy
No. patients   11   13  
Median age, y (range)   46 (15-73)   52 (21-73)  
Sex, no. male/no. female   5/6   8/5  
Median hemoglobin level, g/L   97   99  
Median WBC count, × 109/L (range)   4.5 (1.6-7.4)   4.2 (0.9-32.3)  
Median platelet count, × 109/L   55   45  
Immunophenotype*  B lineage   B lineage  
CD19+CD10-CD20-, % (no. patients)   27 (3)   16.6 (2)  
CD19+CD10+CD20+, % (no. patients)   73 (8)   83.3 (10)  
CR rates, %  70   46  
OS, mos.   11.1   8.1  
Median DFS, mos.
 
5
 
18.2
 
*

Not done for one patient.

P not significant because of the small number of patients in each group.

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