Comparison of DT388GMCSF efficacy (IC50) and GMCSFR expression levels
Cell line . | GMCSFR levels, receptors/cell . | DT388GMCSF, IC50, pM . |
|---|---|---|
| TF1-HaRas | 11 430 | 0.27 |
| U937 | 2 329 | 0.47 |
| TF1-vRaf | 7 624 | 0.64 |
| TF1-vSrc | 5 846 | 0.84 |
| ML2 | 1 209 | 1.9 |
| KG-1 | 869 | 2.5 |
| HL60 | 3 262 | 2.7 |
| ML 17 | 456 | 3.1 |
| Monomac 1 | 304 | 3.2 |
| Sig M5 | 236 | 21 |
| ML-1 | 358 | 22 |
| Monomac 6 | 712 | 68.3 |
| CTV-1 | 108 | >4000 |
Cell line . | GMCSFR levels, receptors/cell . | DT388GMCSF, IC50, pM . |
|---|---|---|
| TF1-HaRas | 11 430 | 0.27 |
| U937 | 2 329 | 0.47 |
| TF1-vRaf | 7 624 | 0.64 |
| TF1-vSrc | 5 846 | 0.84 |
| ML2 | 1 209 | 1.9 |
| KG-1 | 869 | 2.5 |
| HL60 | 3 262 | 2.7 |
| ML 17 | 456 | 3.1 |
| Monomac 1 | 304 | 3.2 |
| Sig M5 | 236 | 21 |
| ML-1 | 358 | 22 |
| Monomac 6 | 712 | 68.3 |
| CTV-1 | 108 | >4000 |