Associations with severe malaria in α-thalassemic children younger than 5 years of age
. | Heterozygous α+-thalassemia . | Homozygous α+-thalassemia . |
|---|---|---|
| Univariate analysis (OR, 95% CI) | ||
| Severe malaria vs all controls | 0.65 (0.47-0.90); P = .008 | 1.32 (0.63-2.60); P = .40 |
| Severe malaria vs aparasitemic controls | 0.67 (0.47-0.96); P = .02 | 1.27 (0.55-2.85); P = .53 |
| Severe malaria vs parasitemic controls | 0.64 (0.45-0.90); P = .008 | 1.36 (0.61-2.95); P = .40 |
| Multivariate analysis (OR, 95% CI) | ||
| Severe malaria vs all controls | 0.71 (0.51-0.99); P = .04 | 1.47 (0.73-2.96); P = .28 |
| Severe malaria vs aparasitemic controls | 0.75 (0.52-1.07); P = .11 | 1.22 (0.57-2.63); P = .60 |
| Severe malaria vs parasitemic controls | 0.52 (0.34-0.78); P = .002 | 1.87 (0.76-4.62); P = .17 |
. | Heterozygous α+-thalassemia . | Homozygous α+-thalassemia . |
|---|---|---|
| Univariate analysis (OR, 95% CI) | ||
| Severe malaria vs all controls | 0.65 (0.47-0.90); P = .008 | 1.32 (0.63-2.60); P = .40 |
| Severe malaria vs aparasitemic controls | 0.67 (0.47-0.96); P = .02 | 1.27 (0.55-2.85); P = .53 |
| Severe malaria vs parasitemic controls | 0.64 (0.45-0.90); P = .008 | 1.36 (0.61-2.95); P = .40 |
| Multivariate analysis (OR, 95% CI) | ||
| Severe malaria vs all controls | 0.71 (0.51-0.99); P = .04 | 1.47 (0.73-2.96); P = .28 |
| Severe malaria vs aparasitemic controls | 0.75 (0.52-1.07); P = .11 | 1.22 (0.57-2.63); P = .60 |
| Severe malaria vs parasitemic controls | 0.52 (0.34-0.78); P = .002 | 1.87 (0.76-4.62); P = .17 |
Children with a normal α-globin genotype serve as reference groups. Multivariate ORs are derived from logistic regression models with severe malaria as outcome variable and sex, age (months), and residence (urban/rural) as independent variables. In children 5 years of age or older, α-globin genotypes did not differ significantly between cases and controls.