Distribution of α-globin genotypes in Ghanaian children with severe malaria and in control groups
. | . | Genotype frequencies (no., %) . | . | . | ||
|---|---|---|---|---|---|---|
| Stratum . | No. . | Normal α-globin genotype . | Heterozygous α+-thalassemia . | Homozygous α+-thalassemia . | ||
| Younger than 5 years of age | ||||||
| Severe malaria | 261 | 186 (71.3) | 62 (23.7) | 13 (5.0) | ||
| All controls | 1093 | 699 (63.9) | 357 (32.7) | 37 (3.4) | ||
| Aparasitemic controls | 479 | 309 (64.5) | 153 (31.9) | 17 (3.6) | ||
| Parasitemic controls | 614 | 390 (63.5) | 204 (33.2) | 20 (3.3) | ||
| 5 years of age or older | ||||||
| Severe malaria cases | 40 | 21 (52.5) | 17 (42.5) | 2 (5.0) | ||
| All controls | 1014 | 636 (62.7) | 329 (32.5) | 49 (4.8) | ||
| Aparasitemic controls | 332 | 211 (63.6) | 103 (31.0) | 18 (5.4) | ||
| Parasitemic controls | 682 | 425 (62.3) | 226 (33.1) | 31 (4.6) | ||
. | . | Genotype frequencies (no., %) . | . | . | ||
|---|---|---|---|---|---|---|
| Stratum . | No. . | Normal α-globin genotype . | Heterozygous α+-thalassemia . | Homozygous α+-thalassemia . | ||
| Younger than 5 years of age | ||||||
| Severe malaria | 261 | 186 (71.3) | 62 (23.7) | 13 (5.0) | ||
| All controls | 1093 | 699 (63.9) | 357 (32.7) | 37 (3.4) | ||
| Aparasitemic controls | 479 | 309 (64.5) | 153 (31.9) | 17 (3.6) | ||
| Parasitemic controls | 614 | 390 (63.5) | 204 (33.2) | 20 (3.3) | ||
| 5 years of age or older | ||||||
| Severe malaria cases | 40 | 21 (52.5) | 17 (42.5) | 2 (5.0) | ||
| All controls | 1014 | 636 (62.7) | 329 (32.5) | 49 (4.8) | ||
| Aparasitemic controls | 332 | 211 (63.6) | 103 (31.0) | 18 (5.4) | ||
| Parasitemic controls | 682 | 425 (62.3) | 226 (33.1) | 31 (4.6) | ||