Table 1.

Characteristics of control group children and severe malaria patients



Control group

Severe malaria patients

All
Aparasitemic children
Parasitemic children
No.   2107   811   1296   301  
Age, mo, median (range)   50 (6-108)*  48 (6-108)*  60 (6-108)*  24 (6-102)  
Proportion younger than 5 y of age, no. (%)   1093 (51.9)*  479 (59.1)*  614 (47.4)*  261 (86.7)  
Female, no. (%)   1050 (49.8)   400 (49.3)   650 (50.2)   159 (52.8)  
Rural residence, no. (%)   1353 (64.2)*  326 (40.2)   1027 (79.2)*  104 (34.6)  
Geometric mean parasite density, per μL (95% CI)   1419 (1274-1581)*  0   1419 (1274-1581)*  27 164 (20 246-36 447)  
Heterozygous α+-thalassemia, no. (%)   686 (32.6)   256 (31.6)   430 (33.2)   79 (26.2) 
Homozygous α+-thalassemia, no. (%)
 
86 (4.1)
 
35 (4.3)
 
51 (3.9)
 
15 (5.0)
 


Control group

Severe malaria patients

All
Aparasitemic children
Parasitemic children
No.   2107   811   1296   301  
Age, mo, median (range)   50 (6-108)*  48 (6-108)*  60 (6-108)*  24 (6-102)  
Proportion younger than 5 y of age, no. (%)   1093 (51.9)*  479 (59.1)*  614 (47.4)*  261 (86.7)  
Female, no. (%)   1050 (49.8)   400 (49.3)   650 (50.2)   159 (52.8)  
Rural residence, no. (%)   1353 (64.2)*  326 (40.2)   1027 (79.2)*  104 (34.6)  
Geometric mean parasite density, per μL (95% CI)   1419 (1274-1581)*  0   1419 (1274-1581)*  27 164 (20 246-36 447)  
Heterozygous α+-thalassemia, no. (%)   686 (32.6)   256 (31.6)   430 (33.2)   79 (26.2) 
Homozygous α+-thalassemia, no. (%)
 
86 (4.1)
 
35 (4.3)
 
51 (3.9)
 
15 (5.0)
 
*

Difference to severe malaria patients, P < .0001.

Difference between aparasitemic and parasitemic control children, P < .0001.

Heterozygous α+-thalassemia occurs less frequently in severe malaria patients than in all controls (P = .03) and than in parasitemic control children (P = .02).

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