Ficoll-purified primary AML cells were analyzed for viability and LDL accumulation in flow cytometry assays performed after cells were cultured for 18 to 24 hours with and without drug treatments (MEV, 12.5 μM; DNR, 0.05 μM; ARA-C, 0.2 μM). Viability data represent flow cytometry assessments of live cell fractions in forward by side light-scatter plots (Figure 3A) and are expressed relative to untreated controls for each sample. The number of samples analyzed and the mean relative viabilities are shown, as are SEM values; x represents assays that were performed with individual AML samples (see data in Figure 5).

MEV indicates mevastatin; other abbreviations are explained in Table 1.

Indicates viabilities that were reduced more than 15% by drug treatments.