Weight loss and hematologic indices from mice treated with vehicle alone (control), Dp44mT, or 3-AP
. | . | Dp44mT . | . | . | . | ||
|---|---|---|---|---|---|---|---|
. | Control . | 0.15 mg/kg . | 0.3 mg/kg . | 0.4 mg/kg . | 3-AP, 6 mg/kg . | ||
| Body weight loss, g | 0.8 ± 0.3 | 1.4 ± 0.2 | 1.3 ± 0.3 | 1.1 ± 0.2 | 5.3 ± 0.4 | ||
| WBC count, × 109/L | 4.4 ± 0.4 | 4.2 ± 0.8 | 4.2 ± 0.4 | 3.9 ± 0.6 | 1.4 ± 0.3 | ||
| RBC count, × 1012/L | 9.1 ± 0.2 | 9.4 ± 0.1 | 8.9 ± 0.4 | 8.0 ± 0.6 | 6.1 ± 0.4 | ||
| Hemoglobin level, g/L | 137 ± 2 | 14.0 ± 2 | 133 ± 5 | 118 ± 8 | 86 ± 5 | ||
| Hematocrit | 0.46 ± 0.01 | 0.46 ± 0.01 | 0.40 ± 0.03 | 0.40 ± 0.01 | 0.28 ± 0.01 | ||
| Platelet count, × 109/L | 788 ± 47 | 1047 ± 42 | 1019 ± 87 | 636 ± 88 | 976 ± 171 | ||
. | . | Dp44mT . | . | . | . | ||
|---|---|---|---|---|---|---|---|
. | Control . | 0.15 mg/kg . | 0.3 mg/kg . | 0.4 mg/kg . | 3-AP, 6 mg/kg . | ||
| Body weight loss, g | 0.8 ± 0.3 | 1.4 ± 0.2 | 1.3 ± 0.3 | 1.1 ± 0.2 | 5.3 ± 0.4 | ||
| WBC count, × 109/L | 4.4 ± 0.4 | 4.2 ± 0.8 | 4.2 ± 0.4 | 3.9 ± 0.6 | 1.4 ± 0.3 | ||
| RBC count, × 1012/L | 9.1 ± 0.2 | 9.4 ± 0.1 | 8.9 ± 0.4 | 8.0 ± 0.6 | 6.1 ± 0.4 | ||
| Hemoglobin level, g/L | 137 ± 2 | 14.0 ± 2 | 133 ± 5 | 118 ± 8 | 86 ± 5 | ||
| Hematocrit | 0.46 ± 0.01 | 0.46 ± 0.01 | 0.40 ± 0.03 | 0.40 ± 0.01 | 0.28 ± 0.01 | ||
| Platelet count, × 109/L | 788 ± 47 | 1047 ± 42 | 1019 ± 87 | 636 ± 88 | 976 ± 171 | ||
Female CD2FI mice, aged 8 to 10 weeks, underwent xenografting with M109 tumor cells. Dp44mT or 3-AP was administered intravenously twice daily for 5 consecutive days from day 4 after tumor implantation. Total body weight was measured on the 12th day after implantation (see “Materials and methods”). Mice were killed, and cardiac puncture was performed. Hematologic indices were measured as described in “Materials and methods.” Results are mean ± SEM (3 separate experiments). WBC indicates white blood cell; RBC, red blood cell.