Table 3.

Prognostic factors for PFS and survival

Estimated 3-y rate (%)
Parameter
No.
PFS
P
Survival
P
Overall   33   66   —   70   —  
Age      
Younger than 30 y   19   72   NS   77   NS  
30 y or older   14   66    64   
Sex      
Male   27   72   NS   73   NS  
Female   6   63    56   
Ann Arbor stage      
I/II   10   86   NS   76   NS  
III/IV   23   70    68   
Mediastinal disease      
Yes   23   59   NS   67   NS  
No   10   83    77   
CNS disease      
Yes   3   33   .02   33   NS  
No   30   74    74   
Adenopathy      
Yes   11   68   NS   72   NS  
No   22   72    71   
Marrow involvement 6%-25%      
Yes   5   100   NS   60   NS  
No   28   72    75   
Hemoglobin      
Lower than 120 g/L   10   71   NS   55   NS  
120 g/L or higher   23   67    77   
Platelet count      
100 × 109/L to 450 × 109/L   30   67   NS   67   NS  
Higher than 450 × 109/L   3   100    100   
LDH (IU/L)      
2 × ULN or less   25   88   NS   73   NS  
More than 2 × ULN   8   65    70   
B symptoms      
Yes   23   69   NS   70   NS  
No   10   71    71   
β2 microglobulin, (n = 30)      
Lower than 3 mg %   27   50   NS   67   NS  
3 mg % or higher   3   76    76   
Immunophenotype (n = 32)      
T cell   26   62   .09   67   NS  
B cell   6   100    80   
Courses to response      
1   19   81   NS   73   NS  
2 or more
 		 14
 		 67
 
 		 68
 
 
Estimated 3-y rate (%)
Parameter
No.
PFS
P
Survival
P
Overall   33   66   —   70   —  
Age      
Younger than 30 y   19   72   NS   77   NS  
30 y or older   14   66    64   
Sex      
Male   27   72   NS   73   NS  
Female   6   63    56   
Ann Arbor stage      
I/II   10   86   NS   76   NS  
III/IV   23   70    68   
Mediastinal disease      
Yes   23   59   NS   67   NS  
No   10   83    77   
CNS disease      
Yes   3   33   .02   33   NS  
No   30   74    74   
Adenopathy      
Yes   11   68   NS   72   NS  
No   22   72    71   
Marrow involvement 6%-25%      
Yes   5   100   NS   60   NS  
No   28   72    75   
Hemoglobin      
Lower than 120 g/L   10   71   NS   55   NS  
120 g/L or higher   23   67    77   
Platelet count      
100 × 109/L to 450 × 109/L   30   67   NS   67   NS  
Higher than 450 × 109/L   3   100    100   
LDH (IU/L)      
2 × ULN or less   25   88   NS   73   NS  
More than 2 × ULN   8   65    70   
B symptoms      
Yes   23   69   NS   70   NS  
No   10   71    71   
β2 microglobulin, (n = 30)      
Lower than 3 mg %   27   50   NS   67   NS  
3 mg % or higher   3   76    76   
Immunophenotype (n = 32)      
T cell   26   62   .09   67   NS  
B cell   6   100    80   
Courses to response      
1   19   81   NS   73   NS  
2 or more
 		 14
 		 67
 
 		 68
 
 

NS indicates not significant; LDH, lactate dehydrogenase; ULN, upper limit normal; and —, not applicable. Courses to respond were 3 (n = 3), 4 (n = 2), or other (5, 8, or 10 courses).

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