IC50 (μM) of imatinib-encapsulated liposomes in leukemia cell lines
. | Bare-liposome . | PEG-liposome . | CD19-liposome . | Free imatinib . |
|---|---|---|---|---|
| OM9;22 | 3.91 ± 0.78* | 5.71 ± 0.88 | 0.90 ± 0.07 | 3.19 ± 0.04 |
| SUP-B15 | 0.60 ± 0.06 | 0.52 ± 0.01 | 0.02 ± 0.001 | 0.25 ± 0.03 |
| KOPN-30 | 0.28 ± 0.03 | 3.68 ± 0.50 | 0.02 ± 0.002 | 0.53 ± 0.01 |
| KOPN-57 | 4.60 ± 0.09 | 5.37 ± 0.004 | 0.13 ± 0.03 | 0.74 ± 0.05 |
| KOPN-72 | 1.46 ± 0.03 | 5.00 ± 0.07 | 0.08 ± 0.002 | 0.65 ± 0.002 |
| BV173 | 3.28 ± 1.17 | 2.66 ± 1.26 | 0.32 ± 0.02 | 0.93 ± 0.09 |
| K562 | 0.49 ± 0.03 | 1.18 ± 0.41 | 1.46 ± 0.62 | 0.37 ± 0.02 |
| Daudi | > 10.0 | > 10.0 | > 10.0 | > 10.0 |
| NB4 | > 10.0 | > 10.0 | > 10.0 | > 10.0 |
. | Bare-liposome . | PEG-liposome . | CD19-liposome . | Free imatinib . |
|---|---|---|---|---|
| OM9;22 | 3.91 ± 0.78* | 5.71 ± 0.88 | 0.90 ± 0.07 | 3.19 ± 0.04 |
| SUP-B15 | 0.60 ± 0.06 | 0.52 ± 0.01 | 0.02 ± 0.001 | 0.25 ± 0.03 |
| KOPN-30 | 0.28 ± 0.03 | 3.68 ± 0.50 | 0.02 ± 0.002 | 0.53 ± 0.01 |
| KOPN-57 | 4.60 ± 0.09 | 5.37 ± 0.004 | 0.13 ± 0.03 | 0.74 ± 0.05 |
| KOPN-72 | 1.46 ± 0.03 | 5.00 ± 0.07 | 0.08 ± 0.002 | 0.65 ± 0.002 |
| BV173 | 3.28 ± 1.17 | 2.66 ± 1.26 | 0.32 ± 0.02 | 0.93 ± 0.09 |
| K562 | 0.49 ± 0.03 | 1.18 ± 0.41 | 1.46 ± 0.62 | 0.37 ± 0.02 |
| Daudi | > 10.0 | > 10.0 | > 10.0 | > 10.0 |
| NB4 | > 10.0 | > 10.0 | > 10.0 | > 10.0 |
Data represent mean ± SD of 3 separate experiments.