Table 4.

Busulfan pharmacokinetic parameters with reference to GSTM1 genotype

Css-1, ng/mL
Cl/F-1, L/h/kg
GSTM1 null   544 ± 184   0.40 ± 0.064  
GSTM1 positive   667 ± 256   0.333 ± 0.071  
P*
 		 .001
 		 .00001
 
Css-1, ng/mL
Cl/F-1, L/h/kg
GSTM1 null   544 ± 184   0.40 ± 0.064  
GSTM1 positive   667 ± 256   0.333 ± 0.071  
P*
 		 .001
 		 .00001
 

Css-1 indicates steady-state concentration after the first dose of busulfan; and Cl/F-1, clearance after the first dose of busulfan.

*

P value calculated by 2-tailed t test

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