Table 1.

Biophysical properties of FE-Pro complex in solution


Ferumoxides, μg/mL

Protamine sulfate, μg/mL

Zeta potential, mV

1/T1

1/T2
100   0   −32.24 ± 0.67   6.64 ± 0.53   101.02 ± 8.60  
100   1   −27.12 ± 0.88*  6.55 ± 0.35   122.31 ± 20.81 
100   3   −16.67 ± 0.43*  4.93 ± 1.32*  60.69 ± 7.74* 
100   5   4.63 ± 0.28*  2.34 ± 0.53*  7.91 ± 1.49* 
100   6   9.92 ± 0.37*  2.56 ± 0.60*  10.42 ± 1.02* 
100   8   19.01 ± 0.67*  4.42 ± 1.72*  141.59 ± 14.28* 
100
 
20
 
20.26 ± 0.34*
 
6.82 ± 0.77
 
152.81 ± 22.29*
 

Ferumoxides, μg/mL

Protamine sulfate, μg/mL

Zeta potential, mV

1/T1

1/T2
100   0   −32.24 ± 0.67   6.64 ± 0.53   101.02 ± 8.60  
100   1   −27.12 ± 0.88*  6.55 ± 0.35   122.31 ± 20.81 
100   3   −16.67 ± 0.43*  4.93 ± 1.32*  60.69 ± 7.74* 
100   5   4.63 ± 0.28*  2.34 ± 0.53*  7.91 ± 1.49* 
100   6   9.92 ± 0.37*  2.56 ± 0.60*  10.42 ± 1.02* 
100   8   19.01 ± 0.67*  4.42 ± 1.72*  141.59 ± 14.28* 
100
 
20
 
20.26 ± 0.34*
 
6.82 ± 0.77
 
152.81 ± 22.29*
 

Data are expressed as mean ± SD. Mean zeta potential of each condition is from 10 readings. For both 1/T1 and 1/T2, relaxation rates are from 5 samples.

*

P < .01, significant differences compared with ferumoxides only.

P < .05, significant differences compared with ferumoxides only.

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