Balanced long-term multilineage reconstitution of cyclin D2–transduced stem cells
. | % Lineage distribution in GFP+ cells (SD) . | . | . | ||
|---|---|---|---|---|---|
. | B cells . | T cells . | Myeloid cells . | ||
| Control | 54.4 (19.3) | 31.3 (16.3) | 12.6 (9.4) | ||
| Cyclin D2 | 46.2 (16.3) | 38.5 (16.6) | 16.2 (9.0) | ||
. | % Lineage distribution in GFP+ cells (SD) . | . | . | ||
|---|---|---|---|---|---|
. | B cells . | T cells . | Myeloid cells . | ||
| Control | 54.4 (19.3) | 31.3 (16.3) | 12.6 (9.4) | ||
| Cyclin D2 | 46.2 (16.3) | 38.5 (16.6) | 16.2 (9.0) | ||
Data show 4 months of analysis of multilineage PB reconstitution in mice that received transplants of LSK cells transduced with control or cyclin D2–containing vectors (same mice as analyzed in Figure 3A). Donor-revived (GFP+) B cells were identified as B220+ cells, T cells as CD3+ cells, and myeloid cells as CD11b/Gr1+B220-CD3- cells. Data are mean (SD) values from 14 (control) and 12 (cyclin D2) mice in a total of 3 experiments.