Experimental models
Transplantation setting, donor, model . | Tumor inoculum . |
|---|---|
| Syngeneic | |
| [C57BL/6 × BALB/c]F1 | |
| F1 → F1: MCA205 | MCA205 (C57BL/6 derived) |
| F1 → F1: MethA | MethA (BALB/c derived) |
| F1 → F1: CMS5 | CMS5 (BALB/c derived) |
| Allogeneic | |
| BALB/c | |
| BALB/c → F1: MCA205 | MCA205 (C57BL/6 derived) |
| BALB/c → F1: MethA | MethA (BALB/c derived) |
| BALB/c → F1: CMS5 | CMS5 (BALB/c derived) |
| C57BL/6* | |
| C57BL/6* → F1: MCA205 | MCA205 (C57BL/6 derived) |
| C57BL/6 → F1: MethA | MethA (BALB/c derived) |
| C57BL/6 → F1: CMS5 | CMS5 (BALB/c derived) |
Transplantation setting, donor, model . | Tumor inoculum . |
|---|---|
| Syngeneic | |
| [C57BL/6 × BALB/c]F1 | |
| F1 → F1: MCA205 | MCA205 (C57BL/6 derived) |
| F1 → F1: MethA | MethA (BALB/c derived) |
| F1 → F1: CMS5 | CMS5 (BALB/c derived) |
| Allogeneic | |
| BALB/c | |
| BALB/c → F1: MCA205 | MCA205 (C57BL/6 derived) |
| BALB/c → F1: MethA | MethA (BALB/c derived) |
| BALB/c → F1: CMS5 | CMS5 (BALB/c derived) |
| C57BL/6* | |
| C57BL/6* → F1: MCA205 | MCA205 (C57BL/6 derived) |
| C57BL/6 → F1: MethA | MethA (BALB/c derived) |
| C57BL/6 → F1: CMS5 | CMS5 (BALB/c derived) |
All recipients are [C57BL/6 × BALB/c]F1.
MHC background of CD8−/−, CD4−/−, perforin−/−, and FasL-deficient donors used in the experiments was identical to that of C57BL/6.