Perindopril increases the size of the pool of Lin–cells in the bone marrow of recipient mice irradiated with a sublethal dose 3 months after grafting
. | n . | % Lin- . | % MNC Lin- . | % LSK in Lin- cells . | % LSK in total marrow . |
|---|---|---|---|---|---|
| Control mice | 6 | 5.93 ± 2.1 | 4 ± 1.33 | 7.68 ± 2.36 | 0.31 ± 0.14 |
| Irradiated mice | 2 | 3.24 ± 1.08 | 2.36 ± 0.74 | 4.88 ± 0.28 | 0.12 ± 0.04 |
| Transplantation from normal mice | 8 | 4.82 ± 1.08 | 3.12 ± 1.33 | 7.68 ± 2.36 | 0.31 ± 0.14 |
| Transplantation from irradiated mice | 8 | 3.63 ± 0.54 | 2.23 ± 0.51 | 5.08 ± 1.82 | 0.11 ± 0.05 |
| Transplantation from ACEI treated irradiated mice | 8 | 4.58 ± 1.24 | 2.84 ± 0.9 | 5.09 ± 2.05 | 0.14 ± 0.05 |
| P | NA | NA | .03 | NA | .07 |
. | n . | % Lin- . | % MNC Lin- . | % LSK in Lin- cells . | % LSK in total marrow . |
|---|---|---|---|---|---|
| Control mice | 6 | 5.93 ± 2.1 | 4 ± 1.33 | 7.68 ± 2.36 | 0.31 ± 0.14 |
| Irradiated mice | 2 | 3.24 ± 1.08 | 2.36 ± 0.74 | 4.88 ± 0.28 | 0.12 ± 0.04 |
| Transplantation from normal mice | 8 | 4.82 ± 1.08 | 3.12 ± 1.33 | 7.68 ± 2.36 | 0.31 ± 0.14 |
| Transplantation from irradiated mice | 8 | 3.63 ± 0.54 | 2.23 ± 0.51 | 5.08 ± 1.82 | 0.11 ± 0.05 |
| Transplantation from ACEI treated irradiated mice | 8 | 4.58 ± 1.24 | 2.84 ± 0.9 | 5.09 ± 2.05 | 0.14 ± 0.05 |
| P | NA | NA | .03 | NA | .07 |
B6D2F1 mice (n = 8) were irradiated with a single dose of 10 Gy and were injected with BMCs (106 cells) from perindopril-treated irradiated mice, irradiated mice, or untreated mice.
Each data point represents the mean ± SD of 8 mice by experiments. The Student t test was used to compare irradiated mice with perindopril-treated mice.
MNC indicates mononuclear cell; LSK, Lin- Sca-1+ c-kit+; and NA, not applicable.