Radioprotective effect of perindopril (30 mg/kg) on mice irradiated with 8.3, 8.7, and 9.1 Gy
. | . | 3-day survival rate . | . | . | |
|---|---|---|---|---|---|
| Irradiation dose . | No. of mice . | Irradiated mice, % . | Irradiated mice treated with ACE I, % . | P . | |
| 8.3 Gy | |||||
| Experiment no. 1 | 40 | 25 ± 9.7 | 55 ± 11.1 | < .05 | |
| Experiment no. 2 | 40 | 35 ± 6.7 | 90 ± 10.1 | < .001 | |
| Experiment no. 3 | 60 | 46.7 ± 9.1 | 93.3 ± 4.5 | < .001 | |
| Experiment no. 4 | 60 | 56.7 ± 9.1 | 86.7 ± 6.2 | < .01 | |
| 8.7 Gy | |||||
| Experiment no. 5 | 40 | 5 ± 4.9 | 40 ± 10.9 | < .01 | |
| Experiment no. 6 | 40 | 30 ± 10.2 | 65 ± 10.7 | < .02 | |
| 9.1 Gy | |||||
| Experiment no. 7 | 40 | 0 ± 4.9 | 20 ± 11.1 | < .001 | |
. | . | 3-day survival rate . | . | . | |
|---|---|---|---|---|---|
| Irradiation dose . | No. of mice . | Irradiated mice, % . | Irradiated mice treated with ACE I, % . | P . | |
| 8.3 Gy | |||||
| Experiment no. 1 | 40 | 25 ± 9.7 | 55 ± 11.1 | < .05 | |
| Experiment no. 2 | 40 | 35 ± 6.7 | 90 ± 10.1 | < .001 | |
| Experiment no. 3 | 60 | 46.7 ± 9.1 | 93.3 ± 4.5 | < .001 | |
| Experiment no. 4 | 60 | 56.7 ± 9.1 | 86.7 ± 6.2 | < .01 | |
| 8.7 Gy | |||||
| Experiment no. 5 | 40 | 5 ± 4.9 | 40 ± 10.9 | < .01 | |
| Experiment no. 6 | 40 | 30 ± 10.2 | 65 ± 10.7 | < .02 | |
| 9.1 Gy | |||||
| Experiment no. 7 | 40 | 0 ± 4.9 | 20 ± 11.1 | < .001 | |
Each experiment shows the 30-day survival rate of mice after exposure to a single dose of irradiation.