Comparison of neuropsychological functional outcomes according to MRI pattern of demyelination following hematopoietic cell transplantation for cerebral X-linked adrenoleukodystrophy
. | Parietal-occipital lobes, n = 25 . | Frontal lobes or pyramidal tracts, n = 7 . | Total, n = 32 . | No neuropsychological function assessment after HCT because of death, n = 29 . | P . |
|---|---|---|---|---|---|
| VIQ* | |||||
| Baseline (range) | 99 (59-127) | 89 (70-107) | 98 (59-127) | 92 (74-124) | NS |
| After HCT (range) | 82 (46-123) | 79 (57-113) | 80.5 (46-123) | — | — |
| Mean change (CI) | –13.7 (–20.5 to –6.8) | –6.4 (–17.8 to 4.9) | –12.1 (–17.1 to –7.1) | — | .25 |
| PIQ* | |||||
| Baseline (range) | 96 (45-122.5) | 92 (61-100) | 94.5 (45-122.5) | 77.5 (45-138) | < .01 |
| After HCT (range) | 64 (45-122.5) | 93 (54-108) | 73 (45-122.5) | — | — |
| Mean change (CI) | –21.6 (–30.6 to –12.6) | 0.4 (–6.8 to 7.7) | –16.8 (–24.6 to –8.9) | — | .03 |
. | Parietal-occipital lobes, n = 25 . | Frontal lobes or pyramidal tracts, n = 7 . | Total, n = 32 . | No neuropsychological function assessment after HCT because of death, n = 29 . | P . |
|---|---|---|---|---|---|
| VIQ* | |||||
| Baseline (range) | 99 (59-127) | 89 (70-107) | 98 (59-127) | 92 (74-124) | NS |
| After HCT (range) | 82 (46-123) | 79 (57-113) | 80.5 (46-123) | — | — |
| Mean change (CI) | –13.7 (–20.5 to –6.8) | –6.4 (–17.8 to 4.9) | –12.1 (–17.1 to –7.1) | — | .25 |
| PIQ* | |||||
| Baseline (range) | 96 (45-122.5) | 92 (61-100) | 94.5 (45-122.5) | 77.5 (45-138) | < .01 |
| After HCT (range) | 64 (45-122.5) | 93 (54-108) | 73 (45-122.5) | — | — |
| Mean change (CI) | –21.6 (–30.6 to –12.6) | 0.4 (–6.8 to 7.7) | –16.8 (–24.6 to –8.9) | — | .03 |
VIQ and PIQ baseline evaluations and those after HCT: median (range). Bold denotes statistical comparisons and corresponding P values. VIQ indicates verbal intelligence quotient; PIQ, performance intelligence quotient; CI, 95% confidence interval