Response to treatment of patients treated with CHOP-21, CHOP-14, CHOEP-21, and CHOEP-14 according to the NHL-B1 protocol
Responses . | CHOP-21, % . | CHOP-14, % . | CHOEP-21, % . | CHOEP-14, % . |
|---|---|---|---|---|
| Complete remission | 80.1 (73.4;85.7) | 78.5 (71.6;84.4) | 84.9 (78.9;89.7) | 90.4 (85.1;94.3) |
| Partial remission | 3.4 (1.3;7.3) | 6.4 (3.2;11.2) | 3.2 (1.2;6.9) | 2.8 (0.9;6.5) |
| Stable disease | 1.1 (0.1;4.0) | 2.9 (1.0;6.6) | 1.6 (0.3;4.7) | 0.0 (0.0;2.1) |
| Progressive disease | 10.2 (6.2;15.7) | 5.8 (2.8;10.4) | 7.0 (3.8;11.7) | 3.4 (1.2;7.2) |
| Therapy-associated deaths | 0.0 (0.0;2.1) | 0.0 (0.0;2.1) | 0.5 (0.0;3.0) | 1.1 (0.1;4.0) |
| Unknown response | 0.0 (0.0;2.1) | 0.6 (0.0;3.2) | 0.5 (0.0;3.0) | 0.6 (0.0;3.1) |
| Additional therapy* | 5.1 (2.4;9.5) | 5.8 (2.8;10.4) | 2.2 (0.6;5.4) | 1.7 (0.4;4.9) |
| 5-y EFS† | 54.7 (46.7;62.6) | 60.8 (52.9;68.6) | 69.2 (62.2;76.1) | 69.4 (62.0;76.8) |
| 5-y overall survival† | 74.9 (67.8;81.9) | 85.0 (79.3;90.6) | 83.3 (77.6;88.9) | 85.1 (79.3;90.9) |
Responses . | CHOP-21, % . | CHOP-14, % . | CHOEP-21, % . | CHOEP-14, % . |
|---|---|---|---|---|
| Complete remission | 80.1 (73.4;85.7) | 78.5 (71.6;84.4) | 84.9 (78.9;89.7) | 90.4 (85.1;94.3) |
| Partial remission | 3.4 (1.3;7.3) | 6.4 (3.2;11.2) | 3.2 (1.2;6.9) | 2.8 (0.9;6.5) |
| Stable disease | 1.1 (0.1;4.0) | 2.9 (1.0;6.6) | 1.6 (0.3;4.7) | 0.0 (0.0;2.1) |
| Progressive disease | 10.2 (6.2;15.7) | 5.8 (2.8;10.4) | 7.0 (3.8;11.7) | 3.4 (1.2;7.2) |
| Therapy-associated deaths | 0.0 (0.0;2.1) | 0.0 (0.0;2.1) | 0.5 (0.0;3.0) | 1.1 (0.1;4.0) |
| Unknown response | 0.0 (0.0;2.1) | 0.6 (0.0;3.2) | 0.5 (0.0;3.0) | 0.6 (0.0;3.1) |
| Additional therapy* | 5.1 (2.4;9.5) | 5.8 (2.8;10.4) | 2.2 (0.6;5.4) | 1.7 (0.4;4.9) |
| 5-y EFS† | 54.7 (46.7;62.6) | 60.8 (52.9;68.6) | 69.2 (62.2;76.1) | 69.4 (62.0;76.8) |
| 5-y overall survival† | 74.9 (67.8;81.9) | 85.0 (79.3;90.6) | 83.3 (77.6;88.9) | 85.1 (79.3;90.9) |
Patient populations are as follows: all, N = 710; CHOP-21, n = 176; CHOP-14, n = 172; CHOEP-21, n = 185; and CHOEP-14, n = 177.95% confidence intervals (Cls) are given in parentheses.
Radiotherapy in the absence of bulky disease, more than 6 cycles of chemotherapy, or alternative treatment.
Estimated after a median time of observation of 58 months.