Characteristics of patients included in the NHL-B1 trial
Patient characteristics . | All, % . | CHOP-21, % . | CHOP-14, % . | CHOEP-21, % . | CHOEP-14, % . | P . |
|---|---|---|---|---|---|---|
| Age, y | .951 | |||||
| 18-40 | 32.1 | 33.0 | 32.0 | 33.5 | 29.9 | |
| 41-50 | 23.5 | 21.0 | 25.6 | 23.2 | 24.3 | |
| 51-60 | 44.4 | 46.0 | 42.4 | 43.2 | 45.8 | |
| Sex | .075 | |||||
| Male | 61.7 | 65.3 | 62.2 | 65.4 | 53.7 | |
| Female | 38.3 | 34.7 | 37.8 | 34.6 | 46.3 | |
| Stage | .069 | |||||
| I | 24.2 | 25.0 | 23.3 | 26.5 | 22.0 | |
| II | 45.2 | 43.8 | 45.3 | 44.9 | 46.9 | |
| III | 17.0 | 11.9 | 22.7 | 17.8 | 15.8 | |
| IV | 13.5 | 19.3 | 8.7 | 0.8 | 15.3 | |
| III/IV | 30.6 | 31.3 | 31.4 | 28.6 | 31.1 | .933 |
| Bulky disease, 7.5 cm or more | 27.7 | 27.8 | 27.3 | 27.6 | 28.2 | .998 |
| ECOG performance status | .471 | |||||
| 0 | 72.5 | 73.9 | 73.8 | 71.9 | 70.6 | |
| 1 | 22.1 | 22.2 | 22.1 | 21.1 | 23.2 | |
| 2 | 4.9 | 4.0 | 4.1 | 7.0 | 4.5 | |
| 3 | 0.4 | 0.0 | 0.0 | 0.0 | 1.7 | |
| Higher than 1 | 5.4 | 4.0 | 4.1 | 7.0 | 6.2 | .475 |
| Extranodal sites | .680 | |||||
| No | 56.6 | 54.0 | 55.2 | 60.0 | 57.1 | |
| Yes | 43.4 | 46.0 | 44.8 | 40.0 | 42.9 | |
| More than 1 | 14.6 | 18.2 | 14.5 | 10.8 | 15.3 | .262 |
| Bone marrow involvement | 5.4 | 9.1 | 2.9 | 3.8 | 5.6 | .050 |
| B symptoms | 21.0 | 17.6 | 20.3 | 23.8 | 22.0 | .524 |
| IPI, age adjusted | .008 | |||||
| 0 | 66.8 | 64.8 | 66.3 | 70.3 | 65.5 | |
| 1 | 30.6 | 35.2 | 32.0 | 23.8 | 31.6 | |
| 2 | 2.7 | 0.0 | 1.7 | 5.9 | 2.8 |
Patient characteristics . | All, % . | CHOP-21, % . | CHOP-14, % . | CHOEP-21, % . | CHOEP-14, % . | P . |
|---|---|---|---|---|---|---|
| Age, y | .951 | |||||
| 18-40 | 32.1 | 33.0 | 32.0 | 33.5 | 29.9 | |
| 41-50 | 23.5 | 21.0 | 25.6 | 23.2 | 24.3 | |
| 51-60 | 44.4 | 46.0 | 42.4 | 43.2 | 45.8 | |
| Sex | .075 | |||||
| Male | 61.7 | 65.3 | 62.2 | 65.4 | 53.7 | |
| Female | 38.3 | 34.7 | 37.8 | 34.6 | 46.3 | |
| Stage | .069 | |||||
| I | 24.2 | 25.0 | 23.3 | 26.5 | 22.0 | |
| II | 45.2 | 43.8 | 45.3 | 44.9 | 46.9 | |
| III | 17.0 | 11.9 | 22.7 | 17.8 | 15.8 | |
| IV | 13.5 | 19.3 | 8.7 | 0.8 | 15.3 | |
| III/IV | 30.6 | 31.3 | 31.4 | 28.6 | 31.1 | .933 |
| Bulky disease, 7.5 cm or more | 27.7 | 27.8 | 27.3 | 27.6 | 28.2 | .998 |
| ECOG performance status | .471 | |||||
| 0 | 72.5 | 73.9 | 73.8 | 71.9 | 70.6 | |
| 1 | 22.1 | 22.2 | 22.1 | 21.1 | 23.2 | |
| 2 | 4.9 | 4.0 | 4.1 | 7.0 | 4.5 | |
| 3 | 0.4 | 0.0 | 0.0 | 0.0 | 1.7 | |
| Higher than 1 | 5.4 | 4.0 | 4.1 | 7.0 | 6.2 | .475 |
| Extranodal sites | .680 | |||||
| No | 56.6 | 54.0 | 55.2 | 60.0 | 57.1 | |
| Yes | 43.4 | 46.0 | 44.8 | 40.0 | 42.9 | |
| More than 1 | 14.6 | 18.2 | 14.5 | 10.8 | 15.3 | .262 |
| Bone marrow involvement | 5.4 | 9.1 | 2.9 | 3.8 | 5.6 | .050 |
| B symptoms | 21.0 | 17.6 | 20.3 | 23.8 | 22.0 | .524 |
| IPI, age adjusted | .008 | |||||
| 0 | 66.8 | 64.8 | 66.3 | 70.3 | 65.5 | |
| 1 | 30.6 | 35.2 | 32.0 | 23.8 | 31.6 | |
| 2 | 2.7 | 0.0 | 1.7 | 5.9 | 2.8 |
ECOG indicates Eastern Cooperative Oncology Group. Patient populations are as follows: all, N = 710; CHOP-21, n = 176; CHOP-14, n = 172; CHOEP-21, n = 185; and CHOEP-14, n = 177.
*Calculated for stages I-IV.