MSI analysis of patients with AML/MDS
. | Age at MDS, y . | Transplant type (year) . | Explant histology . | Clinical details . | Status . | Bone marrow findings . | Cytogenetic analysis . | Aza, mo . | Total Aza, mg/kg . | Other treatment . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 68 | OCT (1995) | Coronary heart disease | Jan 2002 Pancytopenia | Alive | Jan 2002 Trilineage MDS (18% blasts) | del (6q), del (7q) | 14.7 | 275 | Steroids, FK506, ATG |
| 2 | 62 | SLT (1993) | Fibrosing alveolitis | 1999 Pancytopenia | Dead | Jul 1999 Trilineage MDS; Aug 1999 Trilineage MDS (7% blasts) | del (9q), –21 | 74 | 554 | CyA, steroids |
| 3 | 60 | OCT (1995) | Dilated cardiomyopathy | 1999 Acute gum swelling | Dead | Jun 1999 AML (FAB type M4Eo) | del (16q) | 43.4 | 1696 | CyA, steroids, ATG |
| 4 | 72 | OCT (1986) | Coronary heart disease | 1994 Pancytopenia | Dead | Aug 1994 Hypoplastic MDS (10% blasts); Apr 1995 MDS (26% blasts) | del (5q), –7, +8 | 91.6 | 3080 | CyA, steroids, TLI |
| 5 | 50 | HLT (1991) | Bronchiectasis | Unexplained anemia | Alive | Nov 1995 Acquired sideroblastic anemia (35% ringed sideroblasts); Jan 2003 (70% ringed sideroblasts) | del (17q) | 59.8 | 1325 | CyA, steroids, ATG |
| 6 | 59 | SLT (1989) | α-1 Antitrypsin deficiency | Pancytopenia | Dead | Hypoplastic trilineage dysplasia (18% blasts) | Complex karyotype with –5, –7 | 132 | 2571 | CyA, FK506, steroids, TLI |
| 7 | ND | CK | Glomerulonephritis | No details | Dead | AML | No details | No details | 50 mg/d | CyA, steroids |
. | Age at MDS, y . | Transplant type (year) . | Explant histology . | Clinical details . | Status . | Bone marrow findings . | Cytogenetic analysis . | Aza, mo . | Total Aza, mg/kg . | Other treatment . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 68 | OCT (1995) | Coronary heart disease | Jan 2002 Pancytopenia | Alive | Jan 2002 Trilineage MDS (18% blasts) | del (6q), del (7q) | 14.7 | 275 | Steroids, FK506, ATG |
| 2 | 62 | SLT (1993) | Fibrosing alveolitis | 1999 Pancytopenia | Dead | Jul 1999 Trilineage MDS; Aug 1999 Trilineage MDS (7% blasts) | del (9q), –21 | 74 | 554 | CyA, steroids |
| 3 | 60 | OCT (1995) | Dilated cardiomyopathy | 1999 Acute gum swelling | Dead | Jun 1999 AML (FAB type M4Eo) | del (16q) | 43.4 | 1696 | CyA, steroids, ATG |
| 4 | 72 | OCT (1986) | Coronary heart disease | 1994 Pancytopenia | Dead | Aug 1994 Hypoplastic MDS (10% blasts); Apr 1995 MDS (26% blasts) | del (5q), –7, +8 | 91.6 | 3080 | CyA, steroids, TLI |
| 5 | 50 | HLT (1991) | Bronchiectasis | Unexplained anemia | Alive | Nov 1995 Acquired sideroblastic anemia (35% ringed sideroblasts); Jan 2003 (70% ringed sideroblasts) | del (17q) | 59.8 | 1325 | CyA, steroids, ATG |
| 6 | 59 | SLT (1989) | α-1 Antitrypsin deficiency | Pancytopenia | Dead | Hypoplastic trilineage dysplasia (18% blasts) | Complex karyotype with –5, –7 | 132 | 2571 | CyA, FK506, steroids, TLI |
| 7 | ND | CK | Glomerulonephritis | No details | Dead | AML | No details | No details | 50 mg/d | CyA, steroids |
Aza indicates azathioprine; OCT, cardiac transplant; SLT, single lung transplant; CK, cadaver kidney transplant; HLT, heart/lung transplant; ATG, antithymocyte globulin; CyA, cyclosporin A; TLI, total lymphoid irradiation; ND, not determined.