Features of AML induced by normal or Hoxa7−/− progenitors transformed by MLL-GAS7
. | Control . | Wild-type . | Hoxa7−/− . |
|---|---|---|---|
| Latency, d | NA | 110 ± 33 | 138 ± 60 |
| WBC, ×109/L | 7.5 ± 1.5 | 87 ± 62 | 60 ± 43 |
| Blasts in PB, % | 0 ± 0 | 43 ± 19 | 25 ± 12 |
| Spleen weight, g | 0.22 ± 0.08 | 1.3 ± 0.31 | 0.9 ± 0.42 |
| Liver weight, g | 0.51 ± 0.12 | 1.64 ± 0.51 | 1.35 ± 0.48 |
. | Control . | Wild-type . | Hoxa7−/− . |
|---|---|---|---|
| Latency, d | NA | 110 ± 33 | 138 ± 60 |
| WBC, ×109/L | 7.5 ± 1.5 | 87 ± 62 | 60 ± 43 |
| Blasts in PB, % | 0 ± 0 | 43 ± 19 | 25 ± 12 |
| Spleen weight, g | 0.22 ± 0.08 | 1.3 ± 0.31 | 0.9 ± 0.42 |
| Liver weight, g | 0.51 ± 0.12 | 1.64 ± 0.51 | 1.35 ± 0.48 |
Values shown are the mean ± SD from wild-type (n = 10) and Hoxa7−/− (n = 6) mice at the time of killing. PB indicates peripheral blood; NA, not applicable.