Gene expression profiles of CD34+CD38- cells derived from human BM and ESCs
. | ESC/BM ratio* . | . | . | ESC/BM ratio† . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene functional classification . | 0.5 or less . | 0.5 to less than 2.0 . | 2.0 or more . | 0.5 or less . | 0.5 to less than 2.0 . | 2.0 or more . | ||||
| All genes | 791 | 494 | 803 | 132 | 128 | 127 | ||||
| Cell surface antigens | 14 | 5 | 33 | 1 | 2 | 3 | ||||
| Transcription | 77 | 39 | 61 | 6 | 10 | 12 | ||||
| Cell cycle | 15 | 3 | 20 | 2 | 2 | 4 | ||||
| Cell adhesion receptors/proteins | 21 | 13 | 31 | 1 | 1 | 3 | ||||
| Immune system proteins | 17 | 4 | 11 | 5 | 1 | 3 | ||||
| Extracellular transport/carrier proteins | 24 | 14 | 19 | 2 | 0 | 3 | ||||
| Oncogenes/tumor suppressor | 13 | 10 | 20 | 3 | 2 | 4 | ||||
| Stress response proteins | 39 | 18 | 26 | 9 | 5 | 4 | ||||
| Membrane channels and transporters | 29 | 32 | 40 | 2 | 9 | 8 | ||||
| Extracellular matrix proteins | 4 | 1 | 7 | 0 | 0 | 1 | ||||
| Trafficking/targeting proteins | 44 | 39 | 50 | 2 | 2 | 14 | ||||
| Metabolism | 97 | 91 | 120 | 15 | 27 | 16 | ||||
| Posttranslation/protein folding | 22 | 26 | 24 | 3 | 7 | 2 | ||||
| Translation | 58 | 40 | 23 | 41 | 21 | 4 | ||||
| Apoptosis-associated proteins | 14 | 4 | 9 | 4 | 0 | 1 | ||||
| RNA processing/turnover/transport | 29 | 22 | 27 | 6 | 11 | 5 | ||||
| DNA binding and chromatin proteins | 22 | 13 | 13 | 6 | 6 | 4 | ||||
| Cell receptors | 41 | 15 | 53 | 2 | 2 | 5 | ||||
| Cell signaling, extracellular communication proteins | 31 | 15 | 26 | 4 | 3 | 3 | ||||
| Intracellular transducers/effectors/modulators | 85 | 51 | 110 | 8 | 7 | 25 | ||||
| Protein turnover | 30 | 27 | 32 | 3 | 8 | 3 | ||||
| Cytoskeleton/mobility proteins | 23 | 27 | 28 | 1 | 6 | 3 | ||||
| DNA synthesis/recombination/repair | 11 | 5 | 19 | 1 | 0 | 4 | ||||
| Hematopoiesis | 79 | 33 | 94 | 12 | 5 | 17 | ||||
| Functionally unclassified | 176 | 67 | 166 | 22 | 12 | 21 | ||||
. | ESC/BM ratio* . | . | . | ESC/BM ratio† . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene functional classification . | 0.5 or less . | 0.5 to less than 2.0 . | 2.0 or more . | 0.5 or less . | 0.5 to less than 2.0 . | 2.0 or more . | ||||
| All genes | 791 | 494 | 803 | 132 | 128 | 127 | ||||
| Cell surface antigens | 14 | 5 | 33 | 1 | 2 | 3 | ||||
| Transcription | 77 | 39 | 61 | 6 | 10 | 12 | ||||
| Cell cycle | 15 | 3 | 20 | 2 | 2 | 4 | ||||
| Cell adhesion receptors/proteins | 21 | 13 | 31 | 1 | 1 | 3 | ||||
| Immune system proteins | 17 | 4 | 11 | 5 | 1 | 3 | ||||
| Extracellular transport/carrier proteins | 24 | 14 | 19 | 2 | 0 | 3 | ||||
| Oncogenes/tumor suppressor | 13 | 10 | 20 | 3 | 2 | 4 | ||||
| Stress response proteins | 39 | 18 | 26 | 9 | 5 | 4 | ||||
| Membrane channels and transporters | 29 | 32 | 40 | 2 | 9 | 8 | ||||
| Extracellular matrix proteins | 4 | 1 | 7 | 0 | 0 | 1 | ||||
| Trafficking/targeting proteins | 44 | 39 | 50 | 2 | 2 | 14 | ||||
| Metabolism | 97 | 91 | 120 | 15 | 27 | 16 | ||||
| Posttranslation/protein folding | 22 | 26 | 24 | 3 | 7 | 2 | ||||
| Translation | 58 | 40 | 23 | 41 | 21 | 4 | ||||
| Apoptosis-associated proteins | 14 | 4 | 9 | 4 | 0 | 1 | ||||
| RNA processing/turnover/transport | 29 | 22 | 27 | 6 | 11 | 5 | ||||
| DNA binding and chromatin proteins | 22 | 13 | 13 | 6 | 6 | 4 | ||||
| Cell receptors | 41 | 15 | 53 | 2 | 2 | 5 | ||||
| Cell signaling, extracellular communication proteins | 31 | 15 | 26 | 4 | 3 | 3 | ||||
| Intracellular transducers/effectors/modulators | 85 | 51 | 110 | 8 | 7 | 25 | ||||
| Protein turnover | 30 | 27 | 32 | 3 | 8 | 3 | ||||
| Cytoskeleton/mobility proteins | 23 | 27 | 28 | 1 | 6 | 3 | ||||
| DNA synthesis/recombination/repair | 11 | 5 | 19 | 1 | 0 | 4 | ||||
| Hematopoiesis | 79 | 33 | 94 | 12 | 5 | 17 | ||||
| Functionally unclassified | 176 | 67 | 166 | 22 | 12 | 21 | ||||
Threshold = 3; BM, 1692; ES, 1494. Due to genes having been classified in multiple categories, the total number of genes listed in this table is not equal to the number of expressed genes (2086).
Genes with expression levels at least 3-fold of background
Genes with expression levels at least 10-fold of background