Table 7.

Summary of patients who received antiresorptive therapy and/or who suffered from osteoporotic fracture after stem cell transplantation (in order of length of follow-up)

Pt. no.
Therapy started (mo)*
Occurrence of fracture
Fracture event (mo)
Clinical data and time of follow-up (mo)
01   Yes (3)†   Yes   Th 10-12, L1-2 (3)∥  28, female, CML, death (9)  
02   No   Yes   Th 11-12, L1 (4)∥  50, female, AML, death# (10)  
03   Yes (21)*   No   —   35, female, AML, death (22)  
04   Yes (12)*   Yes   Femoral neck (22)∥  40, female, ALL, death# (26)  
05   Yes (6)*   No   —   46, female, CML, death# (34)  
06   Yes (9)*   No   —   16, female, AML, alive (41)  
07   Yes (4)*   No   —   28, female, AML, alive (43)  
08   Yes (8)*   No   —   38, female, CML, alive (44)  
09   Yes (19)*   No   —   39, female, MDS, alive (44)  
10   No   Yes   Femoral neck (38)∥  45, female, CML, death# (44)  
11   Yes (29)†   No   Osteoporotic pain syndrome§  42, male, CML, alive (45)  
12   Yes (14)*   No   —   49, female, CML, alive (45)  
13   Yes (3)*   No   —   43, male, NHL, alive (46)  
14   Yes (12)*   No   —   51, male, CML, alive (47)  
15   Yes (32)‡   No   —   37, male, CML, alive (48)  
16   No   Yes   L4 (11)∥  32, female, CML, alive (50)  
17   Yes (5)*   No   —   20, male, MDS, alive (51)  
18   Yes (16)‡   No   —   37, female, MDS, alive (52)  
19   Yes (8)†   Yes   Th 12, L1 (8)∥  22, male, CML, alive (56)  
20   Yes (27)*   No   —   50, male, CML, alive (56)  
21   Yes (9)†   No   Pre-existing osteoporosis§  31, female, CML, alive (56)  
22   Yes (34)*   No   —   47, female, CML, alive (60)  
23   Yes (29)*   No   —   37, female, AML, alive (62)  
24   Yes (58)*   No   —   35, male, CML, alive (67)  
25   Yes (23)*   No   —   35, male, CML, death# (68)  
26   Yes (37)*   No   —   19, male, AML, alive (70)  
27   Yes (19)*   No   —   28, male, CML, alive (73)  
28   Yes (34)†   Yes   Femoral head (34)∥  42, male, CML, alive (74)  
29   Yes (28)*   No   —   54, female, CML, alive (77)  
30   No   Yes   Th 11 (14)   18, male, ALL, alive (78)  
31   Yes (59)*   No   —   42, male, NHL, alive (80)  
32   Yes (67)†   Yes   Ribs, L1, L3 (62)∥  40, male, CML, alive (81)  
33   Yes (39)*   No   —   26, female, AML, alive (82)  
34   Yes (73)†   Yes   8th rib (53)∥  39, male, CML, alive (83)  
35
 		 Yes (50)*
 		 No
 		 —
 		 55, female, CML, alive (93)
 
Pt. no.
Therapy started (mo)*
Occurrence of fracture
Fracture event (mo)
Clinical data and time of follow-up (mo)
01   Yes (3)†   Yes   Th 10-12, L1-2 (3)∥  28, female, CML, death (9)  
02   No   Yes   Th 11-12, L1 (4)∥  50, female, AML, death# (10)  
03   Yes (21)*   No   —   35, female, AML, death (22)  
04   Yes (12)*   Yes   Femoral neck (22)∥  40, female, ALL, death# (26)  
05   Yes (6)*   No   —   46, female, CML, death# (34)  
06   Yes (9)*   No   —   16, female, AML, alive (41)  
07   Yes (4)*   No   —   28, female, AML, alive (43)  
08   Yes (8)*   No   —   38, female, CML, alive (44)  
09   Yes (19)*   No   —   39, female, MDS, alive (44)  
10   No   Yes   Femoral neck (38)∥  45, female, CML, death# (44)  
11   Yes (29)†   No   Osteoporotic pain syndrome§  42, male, CML, alive (45)  
12   Yes (14)*   No   —   49, female, CML, alive (45)  
13   Yes (3)*   No   —   43, male, NHL, alive (46)  
14   Yes (12)*   No   —   51, male, CML, alive (47)  
15   Yes (32)‡   No   —   37, male, CML, alive (48)  
16   No   Yes   L4 (11)∥  32, female, CML, alive (50)  
17   Yes (5)*   No   —   20, male, MDS, alive (51)  
18   Yes (16)‡   No   —   37, female, MDS, alive (52)  
19   Yes (8)†   Yes   Th 12, L1 (8)∥  22, male, CML, alive (56)  
20   Yes (27)*   No   —   50, male, CML, alive (56)  
21   Yes (9)†   No   Pre-existing osteoporosis§  31, female, CML, alive (56)  
22   Yes (34)*   No   —   47, female, CML, alive (60)  
23   Yes (29)*   No   —   37, female, AML, alive (62)  
24   Yes (58)*   No   —   35, male, CML, alive (67)  
25   Yes (23)*   No   —   35, male, CML, death# (68)  
26   Yes (37)*   No   —   19, male, AML, alive (70)  
27   Yes (19)*   No   —   28, male, CML, alive (73)  
28   Yes (34)†   Yes   Femoral head (34)∥  42, male, CML, alive (74)  
29   Yes (28)*   No   —   54, female, CML, alive (77)  
30   No   Yes   Th 11 (14)   18, male, ALL, alive (78)  
31   Yes (59)*   No   —   42, male, NHL, alive (80)  
32   Yes (67)†   Yes   Ribs, L1, L3 (62)∥  40, male, CML, alive (81)  
33   Yes (39)*   No   —   26, female, AML, alive (82)  
34   Yes (73)†   Yes   8th rib (53)∥  39, male, CML, alive (83)  
35
 		 Yes (50)*
 		 No
 		 —
 		 55, female, CML, alive (93)
 

Antiresorptive treatment started for prevention of fracture (*), occurrence of fracture (†), or avascular necrosis (‡).

Pt indicates patient; —, no fracture event.

§

Osteoporotic fractures.

∥

Harmful events other than fracture.

Death due to infectious complications.

#

Death due to disease recurrence.

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