Table 3.

Correlation of steroid intake after allogeneic stem cell transplantation with changes in BMD and body indices

Follow-up to discharge
Follow-up to month 6
Follow-up to month 12
Follow-up to month 24
Follow-up to month 36
Follow-up to month 48
Long-term follow-up
Steroid* † † † † † † † 
    in grams total   4.1 ± 5.5   8.35 ± 6.44   11.7 ± 9.3   15.5 ± 11.9   18.3 ± 14.1   22.3 ± 16.2   20.3 ± 15.3  
    in mg/day   55.6 ± 63.5   42.8 ± 31.9   30 ± 24   20.9 ± 16.7   16.3 ± 13.2   15 ± 11.3   13.5 ± 10.8  
 ‡ ‡ ‡ ‡ ‡ ‡ ‡ 
BMD   0.05 NS   0.21§  0.33  0.38  0.55  0.42∥  0.43 
Spine   0.12 NS   0.28∥  0.36  0.4  0.56  0.42∥  0.43 
BMD   -0.08 NS   -0.009 NS   0.2§  0.24§  0.5  0.35§  0.4∥ 
Femoral neck   -0.03 NS   0.02 NS   0.23§  0.26§  0.51  0.37∥  0.41∥ 
BMD   -0.08 NS   -0.03 NS   0.14 NS   0.27§  0.47  0.22 NS   0.28§ 
Ward triangle   - 0.03 NS   - 0.0035 NS   0.16 NS   0.29§  0.5  0.24 NS   0.31§ 
BMD   - 0.03 NS   - 0.1 NS   0.18§  0.36∥  0.43∥  0.4§  0.48 
Total body   - 0.02 NS   - 0.08 NS   0.18§  0.38  0.44  0.42∥  0.5 
Bone mineral   - 0.02 NS   0.06 NS   0.24§  0.32§  0.37§  0.4§  0.47 
content   - 0.03 NS   0.08 NS   0.25∥  0.32§  0.37§  0.4§  0.48 
Muscle mass   0.04 NS   0.11 NS   0.28§  0.32∥  0.4∥  0.38§  0.42 
plus fat mass   0.05 NS   0.09 NS   0.27§  0.33∥  0.5  0.4§  0.44 
Muscle mass   0.15§  0.48  0.57  0.59  0.5  0.54  0.54 
 		 0.2§
 		 0.52
 		 0.6
 		 0.59
 		 0.5
 		 0.57
 		 0.56
 
Follow-up to discharge
Follow-up to month 6
Follow-up to month 12
Follow-up to month 24
Follow-up to month 36
Follow-up to month 48
Long-term follow-up
Steroid* † † † † † † † 
    in grams total   4.1 ± 5.5   8.35 ± 6.44   11.7 ± 9.3   15.5 ± 11.9   18.3 ± 14.1   22.3 ± 16.2   20.3 ± 15.3  
    in mg/day   55.6 ± 63.5   42.8 ± 31.9   30 ± 24   20.9 ± 16.7   16.3 ± 13.2   15 ± 11.3   13.5 ± 10.8  
 ‡ ‡ ‡ ‡ ‡ ‡ ‡ 
BMD   0.05 NS   0.21§  0.33  0.38  0.55  0.42∥  0.43 
Spine   0.12 NS   0.28∥  0.36  0.4  0.56  0.42∥  0.43 
BMD   -0.08 NS   -0.009 NS   0.2§  0.24§  0.5  0.35§  0.4∥ 
Femoral neck   -0.03 NS   0.02 NS   0.23§  0.26§  0.51  0.37∥  0.41∥ 
BMD   -0.08 NS   -0.03 NS   0.14 NS   0.27§  0.47  0.22 NS   0.28§ 
Ward triangle   - 0.03 NS   - 0.0035 NS   0.16 NS   0.29§  0.5  0.24 NS   0.31§ 
BMD   - 0.03 NS   - 0.1 NS   0.18§  0.36∥  0.43∥  0.4§  0.48 
Total body   - 0.02 NS   - 0.08 NS   0.18§  0.38  0.44  0.42∥  0.5 
Bone mineral   - 0.02 NS   0.06 NS   0.24§  0.32§  0.37§  0.4§  0.47 
content   - 0.03 NS   0.08 NS   0.25∥  0.32§  0.37§  0.4§  0.48 
Muscle mass   0.04 NS   0.11 NS   0.28§  0.32∥  0.4∥  0.38§  0.42 
plus fat mass   0.05 NS   0.09 NS   0.27§  0.33∥  0.5  0.4§  0.44 
Muscle mass   0.15§  0.48  0.57  0.59  0.5  0.54  0.54 
 		 0.2§
 		 0.52
 		 0.6
 		 0.59
 		 0.5
 		 0.57
 		 0.56
 

First row correlation with total steroid dose; second row correlation with steroid dose in milligrams per day.

NS indicates not significant.

*

Steroid dosage expressed in total grams (g) (first row) and milligrams per day since transplantation (second row).

†

The mean ± 1 SD.

‡

The correlation coefficients and P values (categorized into ns = not significant, §P < .05, ∥P ≤ .001, ¶P ≤ .0001).

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