Table 3.

Mutagen-induced chromosome breakage

DEB, 0.1 μg/mL
MMC, 20 ng/mL
Patient
Average no. of aberrations/cell
Cells with aberrations, %
Average no. of aberrations/cell
Cells with aberrations, %
Kindred 1-sibling 2   13.12   98   NE   NE  
Kindred 2-sibling 2
 		 2.68*
 		 71
 		 2.90*
 		 85
 
DEB, 0.1 μg/mL
MMC, 20 ng/mL
Patient
Average no. of aberrations/cell
Cells with aberrations, %
Average no. of aberrations/cell
Cells with aberrations, %
Kindred 1-sibling 2   13.12   98   NE   NE  
Kindred 2-sibling 2
 		 2.68*
 		 71
 		 2.90*
 		 85
 

For FA, the average number of aberrations/cell after DEB is 0.66 to 11.88 and for MMC, 1.19 to 22.96. For healthy controls, respective values are 0.00 to 0.12 and 0.00 to 0.32.

NE indicates not evaluable.

*

Specimen obtained after therapy

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