Table 3. SAM, SAH, SAM/SAH ratio, and... | American Society of Hematology

Table 3.

SAM, SAH, SAM/SAH ratio, and DNA hypomethylation in brain

Genotype and diet	SAM, nmol/g	SAH, nmol/g	SAM/SAH	Global DNA hypomethylation, dpm/0.5μg DNA
*Mthfr*^+/+
Control	13.0 ± 0.5 (23)	1.70 ± 0.16 (23)	8.73 ± 0.64 (23)	1537 ± 267 (7)
HM	16.2 ± 1.9 (19)^*	2.86 ± 0.28 (19)^*	6.56 ± 0.84 (19)^*	2037 ± 520 (7)
LF	12.0 ± 0.8 (8)	3.68 ± 0.32 (8)^*	3.44 ± 0.35 (8)^*	1524 ± 226 (6)
HM/LF	13.4 ± 1.0 (8)	3.04 ± 0.28 (8)^*	4.58 ± 0.41 (8)^*	2663 ± 951 (4)
*Mthfr*^+/-
Control	14.1 ± 0.9 (22)	2.41 ± 0.22 (22)†	6.56 ± 0.45 (22)†	1843 ± 306 (8)
HM	14.5 ± 0.9 (19)	2.47 ± 0.19 (19)	6.50 ± 0.70 (19)	3571 ± 908 (4)†
LF	12.0 ± 0.7 (7)	3.59 ± 0.29 (7)^*	3.51 ± 0.31 (7)^*	2599 ± 350 (6)
HM/LF	13.1 ± 1.1 (8)	3.70 ± 0.36 (8)^*	3.73 ± 0.38 (8)^*	2358 ± 449 (8)

Genotype and diet	SAM, nmol/g	SAH, nmol/g	SAM/SAH	Global DNA hypomethylation, dpm/0.5μg DNA
*Mthfr*^+/+
Control	13.0 ± 0.5 (23)	1.70 ± 0.16 (23)	8.73 ± 0.64 (23)	1537 ± 267 (7)
HM	16.2 ± 1.9 (19)^*	2.86 ± 0.28 (19)^*	6.56 ± 0.84 (19)^*	2037 ± 520 (7)
LF	12.0 ± 0.8 (8)	3.68 ± 0.32 (8)^*	3.44 ± 0.35 (8)^*	1524 ± 226 (6)
HM/LF	13.4 ± 1.0 (8)	3.04 ± 0.28 (8)^*	4.58 ± 0.41 (8)^*	2663 ± 951 (4)
*Mthfr*^+/-
Control	14.1 ± 0.9 (22)	2.41 ± 0.22 (22)†	6.56 ± 0.45 (22)†	1843 ± 306 (8)
HM	14.5 ± 0.9 (19)	2.47 ± 0.19 (19)	6.50 ± 0.70 (19)	3571 ± 908 (4)†
LF	12.0 ± 0.7 (7)	3.59 ± 0.29 (7)^*	3.51 ± 0.31 (7)^*	2599 ± 350 (6)
HM/LF	13.1 ± 1.1 (8)	3.70 ± 0.36 (8)^*	3.73 ± 0.38 (8)^*	2358 ± 449 (8)

Values shown are mean ± SEM. Numbers in parentheses indicate the number of animals in the group.

P < .05 versus animals of the same genotype fed the control diet

P < .05 versus Mthfr^+/+ genotype