Table 2. SAM, SAH, SAM/SAH ratio, and... | American Society of Hematology

Table 2.

SAM, SAH, SAM/SAH ratio, and DNA hypomethylation in liver

Genotype and diet	SAM, nmol/g	SAH, nmol/g	SAM/SAH	Global DNA hypomethylation, dpm/0.5 μg DNA
*Mthfr*^+/+
Control	70.4 ± 4.9 (23)	29.8 ± 2.0 (23)	2.48 ± 0.16 (23)	1279 ± 254 (8)
HM	60.0 ± 5.6 (20)	41.6 ± 3.0 (20)^*	1.55 ± 0.17 (20)^*	1528 ± 190 (8)
LF	31.4 ± 4.5 (8)^*	38.5 ± 5.5 (8)	0.92 ± 0.16 (8)^*	1460 ± 234 (7)
HM/LF	22.1 ± 4.1 (6)^*	40.0 ± 4.4 (7)	0.62 ± 0.17 (7)^*	1740 ± 366 (7)
*Mthfr*^+/-
Control	55.3 ± 5.2 (21)†	35.3 ± 2.5 (21)	1.67 ± 0.18 (21)†	1679 ± 270 (9)
HM	48.5 ± 5.7 (19)	41.1 ± 3.1 (19)	1.25 ± 0.16 (19)^*	1266 ± 204 (7)
LF	27.1 ± 4.4 (8)^*	38.5 ± 5.1 (8)	0.83 ± 0.20 (8)^*	1338 ± 176 (7)
HM/LF	31.2 ± 6.0 (9)^*	44.6 ± 6.1 (9)	0.72 ± 0.09 (9)^*	1469 ± 247 (9)

Genotype and diet	SAM, nmol/g	SAH, nmol/g	SAM/SAH	Global DNA hypomethylation, dpm/0.5 μg DNA
*Mthfr*^+/+
Control	70.4 ± 4.9 (23)	29.8 ± 2.0 (23)	2.48 ± 0.16 (23)	1279 ± 254 (8)
HM	60.0 ± 5.6 (20)	41.6 ± 3.0 (20)^*	1.55 ± 0.17 (20)^*	1528 ± 190 (8)
LF	31.4 ± 4.5 (8)^*	38.5 ± 5.5 (8)	0.92 ± 0.16 (8)^*	1460 ± 234 (7)
HM/LF	22.1 ± 4.1 (6)^*	40.0 ± 4.4 (7)	0.62 ± 0.17 (7)^*	1740 ± 366 (7)
*Mthfr*^+/-
Control	55.3 ± 5.2 (21)†	35.3 ± 2.5 (21)	1.67 ± 0.18 (21)†	1679 ± 270 (9)
HM	48.5 ± 5.7 (19)	41.1 ± 3.1 (19)	1.25 ± 0.16 (19)^*	1266 ± 204 (7)
LF	27.1 ± 4.4 (8)^*	38.5 ± 5.1 (8)	0.83 ± 0.20 (8)^*	1338 ± 176 (7)
HM/LF	31.2 ± 6.0 (9)^*	44.6 ± 6.1 (9)	0.72 ± 0.09 (9)^*	1469 ± 247 (9)

Values shown are mean ± SEM. Numbers in parentheses indicate the number of animals in the group.

dpm indicates disintegrations per minute.

P < .05 versus animals of the same genotype fed the control diet

P < .05 versus Mthfr^+/- genotype