Multivariate analysis of clinical factors
. | Absolute count CD4+25high . | . | . | % CD4+CD25high of CD4+ . | . | . | ||
---|---|---|---|---|---|---|---|---|
. | Regression coefficient . | SE . | P . | Regression coefficient . | SE . | P . | ||
cGVHD | 14.42 | 3.49 | .0002 | 1.74 | 0.70 | .02 | ||
Recipient age | –0.32 | 0.19 | .09 | — | — | — | ||
Time from HSCT, mo | — | — | — | –0.03 | 0.02 | .07 |
. | Absolute count CD4+25high . | . | . | % CD4+CD25high of CD4+ . | . | . | ||
---|---|---|---|---|---|---|---|---|
. | Regression coefficient . | SE . | P . | Regression coefficient . | SE . | P . | ||
cGVHD | 14.42 | 3.49 | .0002 | 1.74 | 0.70 | .02 | ||
Recipient age | –0.32 | 0.19 | .09 | — | — | — | ||
Time from HSCT, mo | — | — | — | –0.03 | 0.02 | .07 |
Multiple regression analyses used a stepwise selection procedure with 10% entry and exit criteria. Univariate analyses of other potential clinical factors that may have influenced CD4+CD25high T-cell numbers included recipient age; time from transplantation; donor source, HLA-identical related donor/VUD; HSC source, bone marrow/PBSCs; conditioning protocol, standard myeloablative/reduced intensity, in vivo T-cell depletion; and prior acute GVHD. Treatment with immunosuppressive medication was not included in the analysis because few patients without cGVHD were on treatment at the time of the study.
— indicates that no statistical correlation was found.