Table 2.

Multivariate analysis of clinical factors



Absolute count CD4+25high


% CD4+CD25high of CD4+


Regression coefficient
SE
P
Regression coefficient
SE
P
cGVHD   14.42   3.49   .0002   1.74   0.70   .02  
Recipient age   –0.32   0.19   .09   —   —   —  
Time from HSCT, mo
 

 

 

 
–0.03
 
0.02
 
.07
 


Absolute count CD4+25high


% CD4+CD25high of CD4+


Regression coefficient
SE
P
Regression coefficient
SE
P
cGVHD   14.42   3.49   .0002   1.74   0.70   .02  
Recipient age   –0.32   0.19   .09   —   —   —  
Time from HSCT, mo
 

 

 

 
–0.03
 
0.02
 
.07
 

Multiple regression analyses used a stepwise selection procedure with 10% entry and exit criteria. Univariate analyses of other potential clinical factors that may have influenced CD4+CD25high T-cell numbers included recipient age; time from transplantation; donor source, HLA-identical related donor/VUD; HSC source, bone marrow/PBSCs; conditioning protocol, standard myeloablative/reduced intensity, in vivo T-cell depletion; and prior acute GVHD. Treatment with immunosuppressive medication was not included in the analysis because few patients without cGVHD were on treatment at the time of the study.

— indicates that no statistical correlation was found.

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