Demographics and MRI data from patients with SCA and TM.
Parameter . | SCA . | TM . | P . | Normal reference range . |
|---|---|---|---|---|
| Age, y | 17.6 ± 1.3 | 15.7 ± 1.4 | .23 | — |
| Sex, M/F | 9/8 | 10/9 | .999 | — |
| Hepatic iron concentration, mg/g dry weight | 19.3 ± 3.7 | 18.4 ± 3.8 | .997 | — |
| Ferritin concentration | 5422 ± 855 | 3648 ± 1378 | .37 | — |
| Transfusion duration, y | 9.3 ± 1.3 | 12.2 ± 1.5 | .20 | — |
| Chelation duration, y | 6.9 ± 1.2 | 9.8 ± 1.5 | .23 | — |
| BSA, m2 | 1.57 ± 0.09 | 1.25 ± 0.06 | .002* | — |
| Pretransfusion hemoglobin level, g/L | 94 ± 1 | 92 ± 1 | .08 | — |
| Heart rate, bpm | 89.6 ± 3.6 | 84.1 ± 3.5 | .18 | — |
| Systolic blood pressure, mm Hg | 116.9 ± 2.5 | 105 ± 2.3 | .001* | — |
| Diastolic blood pressure, mm Hg | 63.5 ± 1.9 | 60.2 ± 1.8 | .02* | — |
| T2*, ms | 38.1 ± 2.5 | 26.1 ± 4.6 | .005* | 25-46 |
| LV ejection fraction, % | 71 ± 2 | 67 ± 2 | .14 | 61-7714 |
| LV end-diastolic volume index, mL/m2 | 90.0 ± 5.4 | 85.9 ± 3.9 | .53 | 36-8014 |
| LV end-systolic volume index, mL/m2 | 26.1 ± 2.2 | 29.1 ± 2.8 | .41 | 5-3114 |
| LV mass index, g/m2 | 77.0 ± 4.8 | 63.4 ± 3.2 | .008* | 6-9514 |
| Cardiac index, L/min/m2 | 5.9 ± 0.5 | 4.6 ± 0.2 | .03* | 1.7-4.013 |
Parameter . | SCA . | TM . | P . | Normal reference range . |
|---|---|---|---|---|
| Age, y | 17.6 ± 1.3 | 15.7 ± 1.4 | .23 | — |
| Sex, M/F | 9/8 | 10/9 | .999 | — |
| Hepatic iron concentration, mg/g dry weight | 19.3 ± 3.7 | 18.4 ± 3.8 | .997 | — |
| Ferritin concentration | 5422 ± 855 | 3648 ± 1378 | .37 | — |
| Transfusion duration, y | 9.3 ± 1.3 | 12.2 ± 1.5 | .20 | — |
| Chelation duration, y | 6.9 ± 1.2 | 9.8 ± 1.5 | .23 | — |
| BSA, m2 | 1.57 ± 0.09 | 1.25 ± 0.06 | .002* | — |
| Pretransfusion hemoglobin level, g/L | 94 ± 1 | 92 ± 1 | .08 | — |
| Heart rate, bpm | 89.6 ± 3.6 | 84.1 ± 3.5 | .18 | — |
| Systolic blood pressure, mm Hg | 116.9 ± 2.5 | 105 ± 2.3 | .001* | — |
| Diastolic blood pressure, mm Hg | 63.5 ± 1.9 | 60.2 ± 1.8 | .02* | — |
| T2*, ms | 38.1 ± 2.5 | 26.1 ± 4.6 | .005* | 25-46 |
| LV ejection fraction, % | 71 ± 2 | 67 ± 2 | .14 | 61-7714 |
| LV end-diastolic volume index, mL/m2 | 90.0 ± 5.4 | 85.9 ± 3.9 | .53 | 36-8014 |
| LV end-systolic volume index, mL/m2 | 26.1 ± 2.2 | 29.1 ± 2.8 | .41 | 5-3114 |
| LV mass index, g/m2 | 77.0 ± 4.8 | 63.4 ± 3.2 | .008* | 6-9514 |
| Cardiac index, L/min/m2 | 5.9 ± 0.5 | 4.6 ± 0.2 | .03* | 1.7-4.013 |
Data represent the mean value ± SE. Right hand column demonstrates 95% confidence intervals for MRI values; however, all statistical comparisons are between the two patient populations. — indicates not assessed.
Significant P value.