Clinical features of the 15 patients with cirrhosis
Patient . | Age at BMT, y . | Sex . | Time from transplantation to cirrhosis diagnosis, y . | Immunosuppressive therapy after 1 year, mo . | Clinical manifestations . | HCV-related disorder . | Genotype . | Cause of death . |
|---|---|---|---|---|---|---|---|---|
| 1 | 10 | M | 5 | 0 | Ascitis, SBP, VH, encephalopathy | — | NA | Liver failure |
| 2 | 15 | M | 15.8 | 0 | Ascitis, EV | — | 1 | HCC |
| 3 | 40 | F | 10.8 | 1 | EV, VH | Cryoglobulinemia, neuropathy | 3 | — |
| 4 | 18 | M | 4 | 0 | Hypersplenism | Sicca syndrome | 2 | Liver failure |
| 5 | 5 | M | 18.7 | 0 | Hypersplenism, EV | — | NA | Liver failure |
| 6 | 35 | F | 12.5 | 0 | Ascitis, SBP, EV, VH | Glomerulonephritis,* PCT | 3 | Liver failure |
| 7 | 34 | M | 13.4 | 0 | EV, VH | Sicca syndrome | 3 | Liver failure |
| 8 | 19 | M | 15.3 | 27 | — | Cryoglobulinemia | NA | — |
| 9 | 22 | M | 17.2 | 0 | — | — | 1 | — |
| 10 | 12 | M | 11.4 | 0 | — | Thrombocytopenia | 3 | — |
| 11 | 24 | M | 11 | 106 | Hypersplenism | Glomerulonephritis* | 1 | HCC |
| 12 | 32 | M | 14 | 17 | — | — | 1 | HCC |
| 13 | 22 | M | 17.4 | 11 | — | — | 1 | — |
| 14 | 33 | M | 15.3 | 96 | Ascitis, SBP, EV, hypersplenism | Glomerulonephritis* | 3 | — |
| 15 | 46 | F | 13.3 | 29 | Ascitis, SBP, EV, VH, encephalopathy | Neuropathy | 3 | — |
Patient . | Age at BMT, y . | Sex . | Time from transplantation to cirrhosis diagnosis, y . | Immunosuppressive therapy after 1 year, mo . | Clinical manifestations . | HCV-related disorder . | Genotype . | Cause of death . |
|---|---|---|---|---|---|---|---|---|
| 1 | 10 | M | 5 | 0 | Ascitis, SBP, VH, encephalopathy | — | NA | Liver failure |
| 2 | 15 | M | 15.8 | 0 | Ascitis, EV | — | 1 | HCC |
| 3 | 40 | F | 10.8 | 1 | EV, VH | Cryoglobulinemia, neuropathy | 3 | — |
| 4 | 18 | M | 4 | 0 | Hypersplenism | Sicca syndrome | 2 | Liver failure |
| 5 | 5 | M | 18.7 | 0 | Hypersplenism, EV | — | NA | Liver failure |
| 6 | 35 | F | 12.5 | 0 | Ascitis, SBP, EV, VH | Glomerulonephritis,* PCT | 3 | Liver failure |
| 7 | 34 | M | 13.4 | 0 | EV, VH | Sicca syndrome | 3 | Liver failure |
| 8 | 19 | M | 15.3 | 27 | — | Cryoglobulinemia | NA | — |
| 9 | 22 | M | 17.2 | 0 | — | — | 1 | — |
| 10 | 12 | M | 11.4 | 0 | — | Thrombocytopenia | 3 | — |
| 11 | 24 | M | 11 | 106 | Hypersplenism | Glomerulonephritis* | 1 | HCC |
| 12 | 32 | M | 14 | 17 | — | — | 1 | HCC |
| 13 | 22 | M | 17.4 | 11 | — | — | 1 | — |
| 14 | 33 | M | 15.3 | 96 | Ascitis, SBP, EV, hypersplenism | Glomerulonephritis* | 3 | — |
| 15 | 46 | F | 13.3 | 29 | Ascitis, SBP, EV, VH, encephalopathy | Neuropathy | 3 | — |
BMT indicates bone marrow transplantation; SBP, spontaneous bacterial peritonitis; VH, variceal hemorrhage; —, none; NA, not available; EV, esophageal varices; HCC, hepatocellular carcinoma; and PCT, porphyria cutanea tarda.
Biopsy-proven glomerulonephritis with glomerular infiltration with monocytes and intraluminal thrombi, without associated cryoglobulinemia.