Clinical characteristics of AML overexpressing Wt-FLT3
UPN . | Age, y . | FAB . | WBC count, × 109/L . | FLT3 transcripts, copies/μg RNA . | Karyotype . | Gene mutations . |
|---|---|---|---|---|---|---|
| UPN 112 | 69 | M4 | 82.2 | 266 947 | Normal | None |
| UPN 185 | 32 | M2 | 30.0 | 516 010 | t(8; 21) | None |
| UPN 187 | 43 | M2 | 24.7 | 561 052 | Normal | None |
| UPN 23 | 64 | M0 | 197.4 | 1 731 514 | Normal | MLL-TD, N-RAS |
| UPN 67 | 21 | M1 | 56.1 | 2 322 706 | Normal | None |
UPN . | Age, y . | FAB . | WBC count, × 109/L . | FLT3 transcripts, copies/μg RNA . | Karyotype . | Gene mutations . |
|---|---|---|---|---|---|---|
| UPN 112 | 69 | M4 | 82.2 | 266 947 | Normal | None |
| UPN 185 | 32 | M2 | 30.0 | 516 010 | t(8; 21) | None |
| UPN 187 | 43 | M2 | 24.7 | 561 052 | Normal | None |
| UPN 23 | 64 | M0 | 197.4 | 1 731 514 | Normal | MLL-TD, N-RAS |
| UPN 67 | 21 | M1 | 56.1 | 2 322 706 | Normal | None |
There were 5 cases whose FLT3 transcript level was more than 200 000 copies/μg RNA in AML without FLT3/ITD. In particular, 2 cases, UPNs 23 and 67, revealed an extremely high level of the FLT3 transcript. The FLT3 products of these 2 cases were tyrosine phosphorylated, as shown in Figure 3C.