Patient characteristics
Characteristics . | Total cohort N = 2837 . | LNH84 N = 779 . | LNH87 N = 954 . | LNH93 N = 1104 . |
|---|---|---|---|---|
| Median age, y (range) | 54 (8-79) | 48 (8-79) | 58 (15-70) | 52 (15-69) |
| Male sex, % | 59 | 62 | 56 | 60 |
| ECOG score greater than 1, % | 21 | 26 | 19 | 18 |
| Stages III-IV, % | 60 | 62 | 59 | 59 |
| LDH above normal, % | 49 | 48 | 48 | 50 |
| Marrow involvement, % | 21 | 29 | 19 | 18 |
| Extranodal greater than 1, % | 36 | 39 | 37 | 34 |
| IPI score, % | ||||
| 0-2 | 66 | 66 | 65 | 67 |
| 3-5 | 34 | 34 | 35 | 33 |
| Diffuse large cell, % | 43 | 53 | 64 | 55 |
| Phenotype cell B, % | NA | NA | 84 | 83 |
| Initial radiotherapy, % | 4 | 6 | 5 | 3 |
| Additional treatments for refractory or relapsing disease | ||||
| No treatment, % | 31 | 34.2 | 36.9 | 21.3 |
| CT, % | 40 | 44 | 37.9 | 37.3 |
| RDTH, % | 2.5 | 3 | 2 | 2.5 |
| RDTH, CT, % | 10.2 | 8.3 | 11.6 | 11.3 |
| CT, ASCT, % | 10.3 | 8.7 | 6.5 | 15.7 |
| CT, ASCT, RDTH, % | 6 | 1.8 | 5.1 | 11.9 |
Characteristics . | Total cohort N = 2837 . | LNH84 N = 779 . | LNH87 N = 954 . | LNH93 N = 1104 . |
|---|---|---|---|---|
| Median age, y (range) | 54 (8-79) | 48 (8-79) | 58 (15-70) | 52 (15-69) |
| Male sex, % | 59 | 62 | 56 | 60 |
| ECOG score greater than 1, % | 21 | 26 | 19 | 18 |
| Stages III-IV, % | 60 | 62 | 59 | 59 |
| LDH above normal, % | 49 | 48 | 48 | 50 |
| Marrow involvement, % | 21 | 29 | 19 | 18 |
| Extranodal greater than 1, % | 36 | 39 | 37 | 34 |
| IPI score, % | ||||
| 0-2 | 66 | 66 | 65 | 67 |
| 3-5 | 34 | 34 | 35 | 33 |
| Diffuse large cell, % | 43 | 53 | 64 | 55 |
| Phenotype cell B, % | NA | NA | 84 | 83 |
| Initial radiotherapy, % | 4 | 6 | 5 | 3 |
| Additional treatments for refractory or relapsing disease | ||||
| No treatment, % | 31 | 34.2 | 36.9 | 21.3 |
| CT, % | 40 | 44 | 37.9 | 37.3 |
| RDTH, % | 2.5 | 3 | 2 | 2.5 |
| RDTH, CT, % | 10.2 | 8.3 | 11.6 | 11.3 |
| CT, ASCT, % | 10.3 | 8.7 | 6.5 | 15.7 |
| CT, ASCT, RDTH, % | 6 | 1.8 | 5.1 | 11.9 |
CT indicates chemotherapy; RDTH, radiotherapy; ASCT, autologous stem cell transplantation; and NA, not available.