Table 2.

Outcome of PNH patients undergoing nonmyeloablative hematopoietic cell transplantation




No. of cells transfused per kg*






Patient no.
Donor HLA match
CD34, × 106/kg
CD3, × 106/kg
ANC nadir, × 103 cells per μL
Acute GVHD grade/system
Chronic GVHD
Day GPI-negative granulocytes disappeared (<0.03%)
Status
Survival after transplantation, days
1   6 of 6   21.1   4.3   0.007   No   Yes/limited   86   Alive   1325+  
         CR   
2   6 of 6   7.1   3.3   0.003   No   Yes/limited   118   Alive   672+  
         CR   
3   6 of 6   4.9   2.5   0.003   III/GI   Yes/limited   39   Alive   356+  
         CR   
4   6 of 6   8.0   3.7   0.002   IV/GI   No   25   Alive   315+  
         CR   
5   6 of 6   13.4   2.6   0.002   No   No   85   Alive   268+  

 

 

 

 

 

 

 

 
CR
 

 



No. of cells transfused per kg*






Patient no.
Donor HLA match
CD34, × 106/kg
CD3, × 106/kg
ANC nadir, × 103 cells per μL
Acute GVHD grade/system
Chronic GVHD
Day GPI-negative granulocytes disappeared (<0.03%)
Status
Survival after transplantation, days
1   6 of 6   21.1   4.3   0.007   No   Yes/limited   86   Alive   1325+  
         CR   
2   6 of 6   7.1   3.3   0.003   No   Yes/limited   118   Alive   672+  
         CR   
3   6 of 6   4.9   2.5   0.003   III/GI   Yes/limited   39   Alive   356+  
         CR   
4   6 of 6   8.0   3.7   0.002   IV/GI   No   25   Alive   315+  
         CR   
5   6 of 6   13.4   2.6   0.002   No   No   85   Alive   268+  

 

 

 

 

 

 

 

 
CR
 

 

HLA indicates human leukocyte antigen; ANC, absolute neutrophil count; GVHD, graft-versus-host disease; GI, gastrointestinal.

*

The number of cells per kilogram of recipient body weight that were transfused.

The percent of GPI-anchored protein-negative granulocytes on last assessment following transplantation.

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