Outcome of PNH patients undergoing nonmyeloablative hematopoietic cell transplantation
. | . | No. of cells transfused per kg* . | . | . | . | . | . | . | . | |
---|---|---|---|---|---|---|---|---|---|---|
Patient no. . | Donor HLA match . | CD34, × 106/kg . | CD3, × 106/kg . | ANC nadir, × 103 cells per μL . | Acute GVHD grade/system . | Chronic GVHD . | Day GPI-negative granulocytes disappeared (<0.03%)† . | Status . | Survival after transplantation, days . | |
1 | 6 of 6 | 21.1 | 4.3 | 0.007 | No | Yes/limited | 86 | Alive | 1325+ | |
CR | ||||||||||
2 | 6 of 6 | 7.1 | 3.3 | 0.003 | No | Yes/limited | 118 | Alive | 672+ | |
CR | ||||||||||
3 | 6 of 6 | 4.9 | 2.5 | 0.003 | III/GI | Yes/limited | 39 | Alive | 356+ | |
CR | ||||||||||
4 | 6 of 6 | 8.0 | 3.7 | 0.002 | IV/GI | No | 25 | Alive | 315+ | |
CR | ||||||||||
5 | 6 of 6 | 13.4 | 2.6 | 0.002 | No | No | 85 | Alive | 268+ | |
CR |
. | . | No. of cells transfused per kg* . | . | . | . | . | . | . | . | |
---|---|---|---|---|---|---|---|---|---|---|
Patient no. . | Donor HLA match . | CD34, × 106/kg . | CD3, × 106/kg . | ANC nadir, × 103 cells per μL . | Acute GVHD grade/system . | Chronic GVHD . | Day GPI-negative granulocytes disappeared (<0.03%)† . | Status . | Survival after transplantation, days . | |
1 | 6 of 6 | 21.1 | 4.3 | 0.007 | No | Yes/limited | 86 | Alive | 1325+ | |
CR | ||||||||||
2 | 6 of 6 | 7.1 | 3.3 | 0.003 | No | Yes/limited | 118 | Alive | 672+ | |
CR | ||||||||||
3 | 6 of 6 | 4.9 | 2.5 | 0.003 | III/GI | Yes/limited | 39 | Alive | 356+ | |
CR | ||||||||||
4 | 6 of 6 | 8.0 | 3.7 | 0.002 | IV/GI | No | 25 | Alive | 315+ | |
CR | ||||||||||
5 | 6 of 6 | 13.4 | 2.6 | 0.002 | No | No | 85 | Alive | 268+ | |
CR |
HLA indicates human leukocyte antigen; ANC, absolute neutrophil count; GVHD, graft-versus-host disease; GI, gastrointestinal.
The number of cells per kilogram of recipient body weight that were transfused.
The percent of GPI-anchored protein-negative granulocytes on last assessment following transplantation.