Correction of the phenotypic defects in Csf1op/Csf1op mice by rhCSF-1, TgC, and TgCS
Defects of Csf1op/Csf1op mice . | rhCSF-1 . | TgC . | TgCS . |
|---|---|---|---|
| Growth retardation | Complete | Complete | Complete |
| Defects of tooth eruption | Partial | Complete | Complete |
| Abnormal male and female reproductive function | Unknown | Complete | Complete |
| Osteopetrosis | Partial | Complete | Partial |
| Deficiency of tissue macrophages | |||
| Adrenal gland | None | Complete | Partial |
| Bladder | Partial | Complete | Complete |
| Dermis | Partial/none | Complete | Complete |
| Kidney cortex | Complete | Complete | Complete |
| Kidney medulla | Complete | Complete | Partial |
| Large intestine | Partial | Complete | Partial |
| Neonatal liver | Complete | Complete | Complete |
| Adult liver | Complete | Unknown | None |
| Peritoneal cavity | None | Complete | Partial |
| Salivary gland (sublinguinal) | Partial | Complete | Complete |
| Spleen | Complete | Complete | Partial |
| Synovial membrane | None | Complete | Complete |
| Hematologic abnormalities | |||
| Lower BM cellularity | Unknown | Complete | Partial |
| Lower % B cells | Unknown | Complete | Partial |
| Higher % granulocytes | Unknown | Complete | Complete |
Defects of Csf1op/Csf1op mice . | rhCSF-1 . | TgC . | TgCS . |
|---|---|---|---|
| Growth retardation | Complete | Complete | Complete |
| Defects of tooth eruption | Partial | Complete | Complete |
| Abnormal male and female reproductive function | Unknown | Complete | Complete |
| Osteopetrosis | Partial | Complete | Partial |
| Deficiency of tissue macrophages | |||
| Adrenal gland | None | Complete | Partial |
| Bladder | Partial | Complete | Complete |
| Dermis | Partial/none | Complete | Complete |
| Kidney cortex | Complete | Complete | Complete |
| Kidney medulla | Complete | Complete | Partial |
| Large intestine | Partial | Complete | Partial |
| Neonatal liver | Complete | Complete | Complete |
| Adult liver | Complete | Unknown | None |
| Peritoneal cavity | None | Complete | Partial |
| Salivary gland (sublinguinal) | Partial | Complete | Complete |
| Spleen | Complete | Complete | Partial |
| Synovial membrane | None | Complete | Complete |
| Hematologic abnormalities | |||
| Lower BM cellularity | Unknown | Complete | Partial |
| Lower % B cells | Unknown | Complete | Partial |
| Higher % granulocytes | Unknown | Complete | Complete |