GVL effect of DLT: EBMT-95 survey
Grade of GVHD . | No. of patients studied . | Responders (%) . |
|---|---|---|
| 0 | 115 | 58 (50) |
| I | 40 | 30 (75) |
| II or higher | 85 | 72 (85) |
Grade of GVHD . | No. of patients studied . | Responders (%) . |
|---|---|---|
| 0 | 115 | 58 (50) |
| I | 40 | 30 (75) |
| II or higher | 85 | 72 (85) |
In the EBMT-95 cohort the frequencies of allogeneic SCT patients showing GVL responses after DLT increased with the severity of GVHD. While 75% of patients with grade I GVHD showed tumor regression, this increased to 85% in patients with GVHD of grade II or greater. Nevertheless, 50% of patients showing no clinical signs of GVHD also showed complete tumor remissions following DLT.